Microwave irradiation in solvent-free conditions:: an eco-friendly methodology to prepare indazoles, pyrazolopyridines and bipyrazoles by cycloaddition reactions

被引：74
作者：
Díaz-Ortiz, A
de la Hoz, A
Langa, F
机构：
[1] Univ Castilla La Mancha, Fac Quim, E-13071 Ciudad Real, Spain
[2] Univ Castilla La Mancha, Fac Ciencias Medioambiente, Toledo 45001, Spain
来源：
GREEN CHEMISTRY | 2000年 / 2卷 / 04期
关键词：
D O I：
10.1039/b003752o
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A study on the behaviour of vinylpyrazoles, pyrazolyl imines and pyrazolyl hydrazones as dienes or dipoles is reported. Cycloaddition of the aforementioned compounds with electron-poor reagents under microwave irradiation in solvent-free conditions permits the preparation of indazoles, pyrazolopyridines and bipyrazoles in moderate to good yields. This represents an eco-friendly, green approach to these valuable pyrazole derivatives that avoids the harsh or highly contaminant conditions involving classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work up procedures, facility of scale up and savings in energy consumption, in addition with higher yields.
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收藏
页码：165 / 172
页数：8
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