Interferon γ-Induced Protein10 Kinetics in Treatment-Naive Versus Treatment-Experienced Patients Receiving Interferon-Free Therapy for Hepatitis C Virus Infection: Implications for the Innate Immune Response

被引：21

作者：

Lin, Jennifer C. ^{[1
]}

Habersetzer, Francois ^{[7
,8
,9
]}

Rodriguez-Torres, Maribel ^{[6
]}

Afdhal, Nezam ^{[3
]}

Lawitz, Eric J. ^{[4
]}

Paulson, Matthew S. ^{[2
]}

Zhu, Yanni ^{[2
]}

Subramanian, Gangadharan Mani ^{[2
]}

McHutchison, John G. ^{[2
]}

Sulkowski, Mark ^{[5
]}

Wyles, David L. ^{[1
]}

Schooley, Robert T. ^{[1
]}

机构：

[1] Univ Calif San Diego, La Jolla, CA 92093 USA

[2] Gilead Sci, Foster City, CA USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Alamo Med Res, San Antonio, TX USA

[5] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[6] Fdn Invest Diego, San Juan, PR USA

[7] Hop Univ Strasbourg, Strasbourg, France

[8] INSERM 1110, Strasbourg, France

[9] Univ Strasbourg, Strasbourg, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 12期

基金：

美国国家卫生研究院;

关键词：

IP-10; hepatitis C; direct-acting antiviral therapy; innate immunity; INDUCIBLE PROTEIN-10; INFLAMMATION; RIBAVIRIN; CORRELATE; FIBROSIS; PREDICTS;

D O I：

10.1093/infdis/jiu325

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We measured interferon gamma-induced protein 10 (IP-10) levels in 428 patients at baseline, week 1, and week 2 of all-oral treatment for hepatitis C virus (HCV) infection. An increased baseline IP-10 level was associated with a T allele in the IL28B gene, an increased alanine aminotransferase level in treatment-naive but not experienced patients, and an increased body mass index. At week 1, the mean decline in plasma IP-10 levels was the same in treatment-naive and treatment-experienced patients (-49%), whereas during week 2 the mean decline in IP-10 levels in treatment-naive patients (-14%) was significantly larger than in treatment-experienced patients (-2%; P =.0176). IP-10 thus may be a surrogate marker of the rate of intracellular viral replication complex decay.

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页码：1881 / 1885

页数：5

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