Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment

被引：257

作者：

Gao, Ge ^{[1
]}

Sun, Xianbao ^{[1
]}

Liang, Gaolin ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, 2 Sipailou Rd, Nanjing 210096, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2021年 / 31卷 / 25期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

mild‐ temperature photothermal therapy; nanoagents; photothermal agents; therapeutic efficacy; tumors; AUTOPHAGY INHIBITION; OXIDE NANOPARTICLES; CARBON NANOTUBES; GOLD-NANORODS; COMBINATION; IMMUNOTHERAPY; HYPERTHERMIA; METABOLISM; CELLS; HSP90;

D O I：

10.1002/adfm.202100738

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photothermal therapy (PTT), which utilizes near-infrared light-absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild-temperature PTT, which circumvents the limitations of conventional PTT (e.g., thermoresistance and adverse effects), is emerging and shows great potential in the forthcoming clinical applications. However, mild-temperature PTT without adjuvant therapy is not able to completely eradicate tumors because its therapeutic efficacy is dramatically impaired by its inferior heat intensity. As a result, strategies capable of enhancing the anticancer efficacy of mild-temperature PTT are urgently necessitated, which mainly rely on on-demand fabrication of functionalized nanoagents. In this review, the strategies of nanoagent-promoted mild-temperature PTT are highlighted. Furthermore, challenges and opportunities in this field are rationally proposed, and hopefully people can be encouraged by this promising anticancer therapy.

引用

页数：14

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