Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT

被引：28

作者：

Piccin, A. ^{[1
,3
]}

McCann, S. ^{[1
]}

Socie, G. ^{[2
]}

Oneto, R. ^{[4
]}

Bacigalupo, A. ^{[4
]}

Locasciulli, A. ^{[5
]}

Marsh, J. ^{[6
]}

Schrezenmeier, H. ^{[7
]}

Tichelli, A. ^{[8
]}

Hand, E. ^{[1
]}

Lawler, M. ^{[1
]}

Passweg, J. ^{[9
]}

机构：

[1] Univ Dublin Trinity Coll, St Jamess Hosp, Dept Haematol, Dublin 8, Ireland

[2] Hop St Louis, Dept Haematol, Paris, France

[3] Osped San Maurizio, Dept Haematol, Bolzano, Italy

[4] Osped San Martino Genova, Dept Haematol, Genoa, Italy

[5] Osped San Camillo, Haematol & SCT Unit, Rome, Italy

[6] Univ London St Georges Hosp, Dept Haematol Med, London, England

[7] Univ Ulm Klinikum, Inst Klim Transfus Med Ulm, Ulm, Germany

[8] Univ Basel Hosp, Dept Haematol, CH-4031 Basel, Switzerland

[9] Univ Hosp Geneva, Dept Med Interne, Geneva, Switzerland

来源：

BONE MARROW TRANSPLANTATION | 2010年 / 45卷 / 06期

关键词：

aplastic anemia; autologous recovery; chimerism; immunosuppression; HSCT; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; HEMATOPOIETIC CHIMERISM; GRAFT-REJECTION; CYCLOPHOSPHAMIDE; SAA;

D O I：

10.1038/bmt.2009.296

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Graft rejection, with persistent pancytopenia, is well documented after allogeneic BMT (hematopoietic SCT (HSCT)) for severe aplastic anemia (SAA) and the prognosis is poor. The recovery of host-hematopoiesis, autologous recovery (AR), after allogeneic HSCT is a rare event and the incidence and long-term survival are unknown. We report a retrospective analysis of consecutive patients in the Aplastic Anaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT-WPSAA) registry between 1973 and 2005. A total of 45 cases of AR, of 1205 patients transplanted for SAA in 57 centers are reported. We describe characteristics and long-term outcome of patients with AR, compared with SAA patients from participating transplant centers without AR (n = 1024) and patients with graft rejection (n = 136) without autologous recovery. The estimated cumulative incidence of AR was 4.2% (3.1-5.6) (confidence interval (CI) 95%) with an OS of 84% (95% CI 83-107%). The OS of the control group was 74% (81-90) at 10 years of follow up, whereas the patients with graft failure had an OS of 16% (CI 12-28%). This retrospective analysis establishes the incidence and long-term survival of patients experiencing AR after allogeneic HSCT for SAA. Bone Marrow Transplantation (2010) 45, 1008-1013; doi:10.1038/bmt.2009.296; published online 16 November 2009

引用

页码：1008 / 1013

页数：6

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