A facile route to diastereomerically pure analogues of castanospermine and australine.

被引：19
作者：
Marek, D
Wadouachi, A
Uzan, R
Beaupere, D
Nowogrocki, G
Laplace, G
机构：
[1] UNIV PICARDIE,CHIM ORGAN LAB,F-80039 AMIENS,FRANCE
[2] ENSC,LAB CRISTALLOCHIM & PHYSICOCHIM SOLIDE,F-59652 VILLENEUVE DASCQ,FRANCE
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 01期
关键词：
D O I：
10.1016/0040-4039(95)02093-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of cysteamine with D-ribofuranose in which a 2,3-O-isopropylidene group was introduced, yielded the 2-(S)-thiazolidine derivative stereoselectively. The following step of cyclisation led to castanospermine and australine analogues, 3 and 4, in good yields. It was shown that the ratio castanospermine/australine analogues was depending on the activating reagent used for the cyclisation step.
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页码：49 / 52
页数：4
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