Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain

被引：41
|
作者：
Reynolds, LM
Cochran, SM
Morris, BJ
Pratt, JA
Reynolds, GP
机构：
[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Glasgow, Yoshitomi Res Inst Neurosci Glasgow, Glasgow G12 8QQ, Lanark, Scotland
来源：
SCHIZOPHRENIA RESEARCH | 2005年 / 73卷 / 2-3期
关键词：
schizophrenia; phencyclidine (PCP); rat; N-methyl-D-aspartate (NMDA) receptor; N-acetylaspartate (NAA); N-acetylaspartylglutamate (NAAG);
D O I：
10.1016/j.schres.2004.02.003
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Administration of phencyclidine (PCP) to both humans and animals models the symptoms of schizophrenia. Brain concentrations of N-acetylaspartate (NAA) are reduced in this disease, reflecting neuronal dysfunction. This study investigates the effects in rats of a chronic intermittent regime of PCP on NAA and its precursor N-acetylaspartylglutamate (NAAG) in rat frontal and temporal cortex, hippocampus and striatum, determined by HPLC. We found significant PCP-induced deficits of NAA and NAAG only in the temporal cortex; NAAG was significantly elevated in the hippocampus. These changes closely reflect postmortem findings reported in schizophrenia. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 152
页数：6
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