Asymmetric organocatalyzed synthesis of coumarin derivatives

被引：10

作者：

Moreira, Natalia M. ^{[1
]}

Martelli, Lorena S. R. ^{[1
]}

Correa, Arlene G. ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Chem, Ctr Excellence Res Sustainable Chem, BR-13565905 Sao Carlos, SP, Brazil

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

基金：

巴西圣保罗研究基金会;

关键词：

asymmetric synthesis; green chemistry; 2H-chromen-2-one; organocatalysis; ENANTIOSELECTIVE CONJUGATE ADDITION; MICHAEL ADDITION; ALPHA; BETA-UNSATURATED KETONES; 1,3-DICARBONYL COMPOUNDS; HYDROGEN-BOND; 4-HYDROXYCOUMARIN; ACETYLCHOLINESTERASE; CYCLOADDITION; TOOL; QUINOLINONES;

D O I：

10.3762/bjoc.17.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coumarin derivatives are essential scaffolds in medicinal and synthetic chemistry. Compounds of this class have shown important activities, such as anticancer and antiparasitic, besides the commercially available drugs. These properties led to the development of efficient and greener synthetic methods to achieve the 2H-chromen-2-one core. In this context, the advances in asymmetric organocatalyzed synthesis of coumarin derivatives are discussed in this review, according to the mode of activation of the catalyst.

引用

页码：1952 / 1980

页数：29

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