Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles - In vitro study

被引：67

作者：

Nesovic, Katarina ^{[1
]}

Jankovic, Ana ^{[1
]}

Radetic, Tamara ^{[1
]}

Vukasinovic-Sekulic, Maja ^{[1
]}

Kojic, Vesna ^{[2
]}

Zivkovic, Ljiljana ^{[3
]}

Peric-Grujic, Aleksandra ^{[1
]}

Rhee, Kyong Yop ^{[4
]}

Miskovic-Stankovic, Vesna ^{[1
,4
]}

机构：

[1] Univ Belgrade, Fac Technol & Met, Karnegijeva 4, Belgrade, Serbia

[2] Univ Novi Sad, Oncol Inst Vojvodina, Put Dr Goldmana 4, Sremska Kamenica, Serbia

[3] Univ Belgrade, Vinca Inst Nucl Sci, Mike Petrov Alasa 12-14, Belgrade 11000, Serbia

[4] Kyung Hee Univ, Coll Engn, Dept Mech Engn, Yongin 446701, South Korea

来源：

EUROPEAN POLYMER JOURNAL | 2019年 / 121卷

基金：

新加坡国家研究基金会;

关键词：

Chitosan hydrogel; Silver nanoparticles; Antibacterial wound dressings; Release profiles; Swelling kinetics; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; MECHANICAL-PROPERTIES; GAMMA-IRRADIATION; SURFACE-DEFECTS; CROSS-LINKING; RELEASE; WATER; NANOCRYSTALS; ADSORPTION;

D O I：

10.1016/j.eurpolymj.2019.109257

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this work, we provide a facile path for the preparation of wound dressing materials with improved characteristics based on biocompatible chitosan and poly(vinyl alcohol) hydrogels with embedded silver nanoparticles (AgNPs) as a potent antimicrobial agent. The hydrogels were prepared via freezing-thawing method, whereas AgNPs were synthesized via an in situ electrochemical route. The excellent physicochemical properties of the obtained nanocomposite hydrogels were validated using different spectroscopic and microscopic techniques. The formation of sub-10 nm AgNPs was confirmed by UV-visible spectroscopy, dynamic light scattering and transmission electron microscopy. Swelling and silver release profiles were validated using several diffusion models. The hydrogels were proven to be non-cytotoxic using MTT test and possessed powerful antibacterial activity against Staphylococcus aureus and Escherichia coli, as determined by test in suspension, which affirmed their feasibility for wound dressing applications.

引用

页数：17

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