A diastereoselective synthesis of 2,4-disubstituted piperidines: Scaffolds for drug discovery

被引：331

作者：

Watson, PS ^{[1
]}

Jiang, B ^{[1
]}

Scott, B ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Wilmington, DE 19880 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006589o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.

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页码：3679 / 3681

页数：3

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