Dysbiotic microbiota interactions in Crohn's disease

被引：67

作者：

Caparros, Esther ^{[1
,2
]}

Wiest, Reiner ^{[3
]}

Scharl, Michael ^{[4
]}

Rogler, Gerhard ^{[4
]}

Gutierrez Casbas, Ana ^{[2
,5
]}

Yilmaz, Bahtiyar ^{[3
]}

Wawrzyniak, Marcin ^{[4
]}

Frances, Ruben ^{[1
,2
,5
]}

机构：

[1] Univ Miguel Hernandez, Dept Medicina Clin, Alacant, Spain

[2] Hosp Gen Univ Alicante, Iis Isabial, Alicante, Spain

[3] Univ Bern, Univ Hosp Bern, Dept Visceral Surg & Med, Dept Biomed Res, Bern, Switzerland

[4] Univ Zurich, Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Zurich, Switzerland

[5] Inst Salud Carlos III, CIBERehd, Madrid, Spain

来源：

GUT MICROBES | 2021年 / 13卷 / 01期

关键词：

Crohn's disease; microbiota; inflammation; fibrosis; dysbiosis; bacterial translocation; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; GENOME-WIDE ASSOCIATION; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL DENDRITIC CELLS; GUT MUCOSAL MICROBIOTA; SUSCEPTIBILITY LOCI; NATURAL-HISTORY; T-CELLS; TRANSLOCATION;

D O I：

10.1080/19490976.2021.1949096

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.

引用

页数：19

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