Penarolide sulfates A1 and A2, new α-glucosidase inhibitors from a marine sponge Penares sp.

被引：34

作者：

Nakao, Y

Maki, T

Matsunaga, S

van Soest, RWM

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Univ Amsterdam, Inst Systemat & Ecol, NL-1090 GT Amsterdam, Netherlands

来源：

TETRAHEDRON | 2000年 / 56卷 / 46期

关键词：

enzyme inhibitors; macrolides; marine metabolites; mass spectrometry; sponge;

D O I：

10.1016/S0040-4020(00)00750-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penarolide sulfates A(1) (1) and A(2) (2) have been isolated as alpha -glucosidase inhibitors from a marine sponge Penares sp.(1) Their structures including absolute stereochemistry were determined to be unique 30- and 31-membered macrolides encompassing a proline residue and three sulfate groups by interpretation of spectral data and chemical degradation. Penarolide sulfates Al (1) and A2 (2) inhibit alpha -glucosidase with IC50 values of 1.2 and 1.5 mug/mL, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8977 / 8987

页数：11

共 27 条

[1] CHARGE-REMOTE FRAGMENTATIONS - ANALYTICAL APPLICATIONS AND FUNDAMENTAL-STUDIES [J].