Characteristics of Tau and Its Ligands in PET Imaging

被引：87

作者：

Harada, Ryuichi ^{[1
]}

Okamura, Nobuyuki ^{[1
,2
]}

Furumoto, Shozo ^{[3
]}

Tago, Tetsuro ^{[3
]}

Yanai, Kazuhiko ^{[2
]}

Arai, Hiroyuki ^{[4
]}

Kudo, Yukitsuka ^{[1
,3
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc, Div Neuroimaging, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Dept Pharmacol, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

[3] Tohoku Univ, Ctr Cyclotron & Radioisotope, Div Radiopharmaceut Chem, Aoba Ku, 6-3Aoba, Sendai, Miyagi 9808578, Japan

[4] Tohoku Univ, Inst Dev Aging & Canc, Dept Geriatr & Gerontol, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

来源：

BIOMOLECULES | 2016年 / 6卷 / 01期

关键词：

radiotracer; Alzheimer's disease; tau deposits; positron emission tomography; POSITRON-EMISSION-TOMOGRAPHY; PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE BRAIN; BETA-AMYLOID PLAQUES; NEUROFIBRILLARY TANGLES; PICKS-DISEASE; THIAZIN RED; CORTICOBASAL DEGENERATION; BINDING CHARACTERISTICS; PROTEIN-TAU;

D O I：

10.3390/biom6010007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tau deposition is one of the neuropathological hallmarks in Alzheimer's disease as well as in other neurodegenerative disorders called tauopathies. Recent efforts to develop selective tau radiopharmaceuticals have allowed the visualization of tau deposits in vivo. In vivo tau imaging allows the assessment of the regional distribution of tau deposits in a single human subject over time for determining the pathophysiology of tau accumulation in aging and neurodegenerative conditions as well as for application in drug discovery of anti-dementia drugs as surrogate markers. However, tau deposits show complicated characteristics because of different isoform composition, histopathology, and ultrastructure in various neurodegenerative conditions. In addition, since tau radiopharmaceuticals possess different chemotype classes, they may show different binding characteristics with heterogeneous tau deposits. In this review, we describe the characteristics of tau deposits and their ligands that have beta-sheet binding properties, and the status of tau imaging in clinical studies.

引用

页码：2 / 15

页数：15

共 110 条

[1] Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for β-amyloid plaques in Alzheimer's disease [J].

Agdeppa, ED ;

Kepe, V ;

Liu, J ;

Flores-Torres, S ;

Satyamurthy, N ;

Petric, A ;

Cole, GM ;

Small, GW ;

Huang, SC ;

Barrio, JR .

JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :art. no.-RC189

[2] In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-{6-[(2[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile [J].

Agdeppa, ED ;

Kepe, V ;

Petric, A ;

Satyamurthy, N ;

Liu, J ;

Huang, SC ;

Small, GW ;

Cole, GM ;

Barrio, JR .

NEUROSCIENCE, 2003, 117 (03) :723-730

[3] Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future [J].

Ariza, Manuela ;

Kolb, Hartmuth C. ;

Moechars, Dieder ;

Rombouts, Frederik ;

Ignacio Andres, Jose .

JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (11) :4365-4382

[4] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[5] Tau-mediated neurodegeneration in Alzheimer's disease and related disorders [J].

Ballatore, Carlo ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) :663-672

[6] In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging [J].

Barrio, Jorge R. ;

Small, Gary W. ;

Wong, Koon-Pong ;

Huang, Sung-Cheng ;

Liu, Jie ;

Merrill, David A. ;

Giza, Christopher C. ;

Fitzsimmons, Robert P. ;

Omalu, Bennet ;

Bailes, Julian ;

Kepe, Vladimir .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (16) :E2039-E2047

[7] NEOCORTICAL NEUROFIBRILLARY TANGLES CORRELATE WITH DEMENTIA SEVERITY IN ALZHEIMERS-DISEASE [J].

BIERER, LM ;

HOF, PR ;

PUROHIT, DP ;

CARLIN, L ;

SCHMEIDLER, J ;

DAVIS, KL ;

PERL, DP .

ARCHIVES OF NEUROLOGY, 1995, 52 (01) :81-88

[8] THE SWITCH OF TAU-PROTEIN TO AN ALZHEIMER-LIKE STATE INCLUDES THE PHOSPHORYLATION OF 2 SERINE PROLINE MOTIFS UPSTREAM OF THE MICROTUBULE BINDING REGION [J].

BIERNAT, J ;

MANDELKOW, EM ;

SCHROTER, C ;

LICHTENBERGKRAAG, B ;

STEINER, B ;

BERLING, B ;

MEYER, H ;

MERCKEN, M ;

VANDERMEEREN, A ;

GOEDERT, M ;

MANDELKOW, E .

EMBO JOURNAL, 1992, 11 (04) :1593-1597

[9]

BINDER LI, 1985, J CELL BIOL, V101, P1371, DOI 10.1083/jcb.101.4.1371

[10] A SEQUENCE OF CYTOSKELETON CHANGES RELATED TO THE FORMATION OF NEUROFIBRILLARY TANGLES AND NEUROPIL THREADS [J].

BRAAK, E ;

BRAAK, H ;

MANDELKOW, EM .

ACTA NEUROPATHOLOGICA, 1994, 87 (06) :554-567

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