Microbial Metabolites of Flavan-3-Ols and Their Biological Activity

被引：55

作者：

Marquez Campos, Estefania ^{[1
,2
]}

Stehle, Peter ^{[2
]}

Simon, Marie-Christine ^{[1
]}

机构：

[1] Univ Bonn, Dept Nutr & Food Sci, Nutr & Microbiota, D-53115 Bonn, Germany

[2] Univ Bonn, Dept Nutr & Food Sci, Nutr Physiol, D-53115 Bonn, Germany

来源：

NUTRIENTS | 2019年 / 11卷 / 10期

关键词：

polyphenols; flavonoids; microbiota; metabolism; UROPATHOGENIC ESCHERICHIA-COLI; GREEN TEA FLAVAN-3-OLS; PANCREATIC BETA-CELLS; PROTOCATECHUIC ACID; 3,4-DIHYDROXYPHENYLACETIC ACID; OXIDATIVE STRESS; ANTIADHESIVE ACTIVITY; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; BLOOD-PRESSURE;

D O I：

10.3390/nu11102260

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Flavan-3-ols are the main contributors to polyphenol intake. Many varying beneficial health effects in humans have been attributed to them, including the prevention of cardiovascular disease and cancer. Nevertheless, the mechanisms by which these flavonoids could exert beneficial functions are not entirely known. Several in vitro studies and in vivo animal models have tried to elucidate the role of the specific colonic metabolites on the health properties that are attributed to the parent compounds since a larger number of ingested flavan-3-ols reach the colon and undergo there microbial metabolism. Many new studies about this topic have been performed over the last few years and, to the best of our knowledge, no scientific literature review regarding the bioactivity of all identified microbial metabolites of flavan-3-ols has been recently published. Therefore, the aim of this review is to present the current status of knowledge on the potential health benefits of flavan-3-ol microbial metabolites in humans while using the latest evidence on their biological activity.

引用

页数：27

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