68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy

被引：33

作者：

Bouziotis, Penelope ^{[1
]}

Stellas, Dimitris ^{[2
]}

Thomas, Eloise ^{[3
]}

Truillet, Charles ^{[3
]}

Tsoukalas, Charalampos ^{[1
]}

Lux, Francois ^{[3
]}

Tsotakos, Theodoros ^{[1
]}

Xanthopoulos, Stavros ^{[1
]}

Paravatou-Petsotas, Maria ^{[1
]}

Gaitanis, Anastasios ^{[2
]}

Moulopoulos, Lia Angela ^{[4
]}

Koutoulidis, Vassilis ^{[4
]}

Anagnostopoulos, Constantinos D. ^{[2
]}

Tillement, Olivier ^{[3
]}

机构：

[1] Natl Ctr Sci Res Demokritos, Inst Nucl & Radiol Sci & Technol Energy & Safety, Athens 15310, Greece

[2] Acad Athens, Biomed Res Fdn, 4 Soranou Ephessiou St, Athens 11527, Greece

[3] Univ Lyon 1, CNRS, UMR5306, Inst Lumiere Mat, F-69622 Villeurbanne, France

[4] Natl & Kapodistrian Univ Athens, Sch Med, Dept Radiol 1, 76 Vasilissis Sofias Ave, Athens 11528, Greece

来源：

NANOMEDICINE | 2017年 / 12卷 / 13期

关键词：

Gallium-68; PET/MR imaging; ultrasmall AGuIX nanoparticles; GADOLINIUM-BASED NANOPARTICLES; TUMOR; RGD; BIODISTRIBUTION; CLEARANCE; PARTICLES; PROBES; MRI; PET;

D O I：

10.2217/nnm-2017-0032

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (Ga-68). Materials & methods: AGuIX@NODAGA nanoparticles were labeled with Ga-68 at high efficiency. Tumor accumulation in an appropriate disease model was assessed by ex vivo biodistribution and in vivo PET/MR imaging. Results: Ga-68-AGuIX@NODAGA was proven to passively accumulate in U87MG human glioblastoma tumor xenografts. Metabolite assessment in serum, urine and tumor samples showed that Ga-68-AGuIX@NODAGA remains unmetabolized up to at least 60 min postinjection. Conclusion: This study demonstrates that Ga-68-AGuIX@NODAGA can be used as a dual-modality PET/MR imaging agent with passive accumulation in the diseased area, thus showing great potential for PET/MR image-guided radiation therapy.

引用

页码：1561 / 1574

页数：14

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