One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from terminal acetylenes and in situ generated azides

被引：72
|
作者：
Odlo, Kristin [1 ]
Hoydahl, Edmund Andre [1 ]
Hansen, Trond Vidar [1 ]
机构：
[1] Univ Oslo, Sch Pharm, Dept Pharmaceut Chem, N-0316 Oslo, Norway
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 12期
关键词：
one-pot reactions; 1,2,3-triazoles; cycloadditions;
D O I：
10.1016/j.tetlet.2007.01.130
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,4-Disubstituted 1,2,3-triazoles were obtained by a high-yielding copper(1) catalyzed 1,3-dipolar cycloaddition reaction between in situ generated azides and terminal acetylenes. This one-pot, two-step procedure tolerates most functional groups and circumvents the problems associated with the isolation of potentially toxic and explosive organic azides. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2097 / 2099
页数：3
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