The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation

被引：87
作者：
Corbeil, Denis [2 ]
Marzesco, Anne-Marie [1 ]
Wilsch-Braeuninger, Michaela [1 ]
Huttner, Wieland B. [1 ]
机构：
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] Tech Univ Dresden, BIOTEC, Tissue Engn Labs, D-01307 Dresden, Germany
来源：
FEBS LETTERS | 2010年 / 584卷 / 09期
关键词：
Cholesterol; Membrane polarity; Microvilli; Primary cilium; Prominin-1; NEURAL-TUBE CLOSURE; EPITHELIAL-CELLS; LIPID RAFTS; NEUROEPITHELIAL CELLS; PROGENITOR CELLS; PRIMARY CILIUM; BASAL PROCESS; STEM; MARKER; MICROVILLI;
D O I：
10.1016/j.febslet.2010.01.050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells, prominin-1 is found in microvilli, the primary cilium and the midbody. These three types of apical membrane protrusions are subject to remodeling during (neuro) epithelial cell differentiation. The protrusion-specific localization of prominin involves its association with a distinct cholesterol-based membrane microdomain. Moreover, the three prominin-1-containing plasma membrane protrusions are the origin of at least two major subpopulations of prominin-1-containing extracellular membrane particles. Intriguingly, the release of these particles has been implicated in (neuro) epithelial cell differentiation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1659 / 1664
页数：6
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