Wisconsin Card Sorting Test and Brain Perfusion Imaging in Early Dementia

被引：16
作者：
Takeda, Naoya [1 ]
Terada, Seishi [1 ]
Sato, Shuhei [2 ]
Honda, Hajime [1 ]
Yoshida, Hidenori [1 ]
Kishimoto, Yuki [1 ]
Kamata, Gosuke [1 ]
Oshima, Etsuko [1 ]
Ishihara, Takeshi [1 ]
Kuroda, Shigetoshi [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008558, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Radiol, Okayama 7008558, Japan
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 29卷 / 01期
关键词：
3DSRT; Cerebral blood flow; Dementia; Single photon emission computed tomography; Wisconsin card sorting test; CEREBRAL-BLOOD-FLOW; FRONTAL ASSESSMENT BATTERY; ALZHEIMERS-DISEASE; INTERNATIONAL WORKSHOP; COGNITIVE IMPAIRMENT; DIAGNOSTIC-CRITERIA; MEMORY-SYSTEMS; AMINE OXIME; PERFORMANCE; TOMOGRAPHY;
D O I：
10.1159/000261645
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background/Aims: The presence of frontal or executive deficits in patients even at early stages of dementia is now widely recognized. We investigated the relationship between the scores of the Wisconsin card sorting test (WCST) and brain perfusion in patients with early dementia. Methods: A total of 77 subjects participated in this study. They underwent the WCST and brain single photon emission computed tomography with 99mTc-ethylcisteinate dimer. We analyzed the data using a regional cerebral blood flow (rCBF) quantification software program, 3DSRT. Results: The number of categories achieved (CA) scores of the WCST had a weakly positive correlation with regional cerebral blood flow in the bilateral precentral, bilateral callosomarginal, bilateral pericallosal, right thalamus, left central and left parietal segments. The number of perseverative errors of the Nelson type (PEN) scores had a weakly negative correlation with rCBF in the right thalamus. Conclusion: The results in this study suggest that CA scores mainly reflect the function of the precentral segments, especially the left side, and that PEN scores correlate with rCBF in the right thalamus. The results suggest that CA scores and PEN scores should be differentially estimated in the WCST. Copyright (C) 2010 S. Karger AG, Basel
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页码：21 / 27
页数：7
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