Relationships Between Physical Activity and Bone Density in People Living with HIV: Results from the SATURN-HIV Study

被引：15

作者：

Perazzo, Joseph D. ^{[1
,2
]}

Webel, Allison R. ^{[3
]}

Alam, S. M. Khurshid ^{[4
]}

Sattar, Abdus ^{[4
]}

McComsey, Grace A. ^{[5
]}

机构：

[1] Univ Cincinnati, Nursing, Cincinnati, OH 45221 USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Frances Payne Bolton Sch Nursing, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Dept Epidemiol & Biostat, Sch Med, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Case Rainbow Babies & Childrens Hosp, Case Med Ctr, Med & Pediat, Cleveland, OH 44106 USA

来源：

JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE | 2018年 / 29卷 / 04期

基金：

美国国家卫生研究院;

关键词：

bone; exercise; HIV; osteoporosis; physical activity; BODY-MASS INDEX; MINERAL DENSITY; ANTIRETROVIRAL TREATMENT; INFECTION; INFLAMMATION; THERAPY; PREVALENCE; INITIATION; FRACTURE; SMOKING;

D O I：

10.1016/j.jana.2018.03.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We conducted a cross-sectional secondary analysis of baseline data from the SATURN-HIV study (N=147; 78% male, 68% Black, median body mass index [BMI] 26.72 kg/m(2), 13% with osteopenia, HIV-1 < RNA, 1,000 copies/mL, stable antiretroviral therapy [ART]) to explore the relationship between physical activity (PA) and bone mineral density (BMD). We measured self-reported minutes of PA and BMD in the overall sample and subgroups based on national recommendations (>= 150 minutes/week). Forty-one (28%) participants met recommended PA levels. Higher intensity PA was associated with higher BMD at the total hip (r = 0.27, p = .09; n = 41; 28%) and lumbar spine (r = 0.32, p < .05), and predicted higher BMD at the hip (p < .01; controlling for age, BMI, ART). Lumbar spine BMD did not retain significance in the regression model. Moderate-tohigh intensity PA could prevent or mitigate excessive bone loss in people living with HIV. Copyright (C) 2018 Association of Nurses in AIDS Care

引用

页码：528 / 537

页数：10

共 50 条

[1]

American Heart Association, 2016, AM HEART ASS REC PHY

[2] Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection:: Indication of normalization of the bone-remodeling process during highly active antiretroviral therapy [J].

Aukrust, P ;

Haug, CJ ;

Ueland, T ;

Lien, E ;

Müller, F ;

Espevik, T ;

Bollerslev, J ;

Froland, SS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (01) :145-150

[3] The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation [J].

Beaupere, Carine ;

Garcia, Marie ;

Larghero, Jerome ;

Feve, Bruno ;

Capeau, Jacqueline ;

Lagathu, Claire .

AGING CELL, 2015, 14 (04) :534-546

[4] Low body weight mediates the relationship between HIV infection and low bone mineral density: A meta-analysis [J].

Bolland, Mark J. ;

Grey, Andrew B. ;

Gamble, Greg D. ;

Reid, Ian R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (12) :4522-4528

[5] Moderate aerobic exercise (brisk walking) increases bone density in cART-treated persons [J].

Bonato, M. ;

Bossolasco, S. ;

Galli, L. ;

Pavei, G. ;

Testa, M. ;

Bertocchi, C. ;

Galvano, E. ;

Balconi, G. ;

Lazzarin, A. ;

Merati, G. ;

La Torre, A. ;

Cinque, P. .

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2012, 15 :49-50

[6] Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study [J].

Bonnet, Eric ;

Ruidavets, Jean-Bernard ;

Genoux, Anne ;

Mabile, Laurence ;

Busato, Florian ;

Obadia, Martine ;

Prevoteau, Francois ;

Marchou, Bruno ;

Massip, Patrice ;

Marion-Latard, Fabrice ;

Delpierre, Cyrille ;

Bernard, Jacques ;

Perret, Bertrand .

BMC INFECTIOUS DISEASES, 2013, 13

[7] Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir [J].

Brown, Todd T. ;

Moser, Carlee ;

Currier, Judith S. ;

Ribaudo, Heather J. ;

Rothenberg, Jennifer ;

Kelesidis, Theodoros ;

Yang, Otto ;

Dube, Michael P. ;

Murphy, Robert L. ;

Stein, James H. ;

McComsey, Grace A. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (08) :1241-1249

[8] Body Composition, Soluble Markers of Inflammation, and Bone Mineral Density in Antiretroviral Therapy-Naive HIV-1-Infected Individuals [J].

Brown, Todd T. ;

Chen, Yun ;

Currier, Judith S. ;

Ribaudo, Heather J. ;

Rothenberg, Jennifer ;

Dube, Michael P. ;

Murphy, Robert ;

Stein, James H. ;

McComsey, Grace A. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2013, 63 (03) :323-330

[9] Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens [J].

Brown, Todd T. ;

Ross, Allison C. ;

Storer, Norma ;

Labbato, Danielle ;

McComsey, Grace A. .

ANTIVIRAL THERAPY, 2011, 16 (07) :1063-1072

[10] Loss of Bone Mineral Density After Antiretroviral Therapy Initiation, Independent of Antiretroviral Regimen [J].

Brown, Todd T. ;

McComsey, Grace A. ;

King, Martin S. ;

Qaqish, Roula B. ;

Bernstein, Barry M. ;

da Silva, Barbara A. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 51 (05) :554-561

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