Protein-ligand binding interactions of imidazolium salts with SARS CoV-2

被引:6
作者
Satheesh, Dhurairaj [1 ,3 ]
Rajendran, Annamalai [2 ]
Chithra, Kasi [3 ]
机构
[1] Bharathiar Univ, Res & Dev Ctr, Coimbatore 641046, Tamil Nadu, India
[2] Sir Theagaraya Coll, Dept Chem, Chennai 600021, Tamil Nadu, India
[3] Loganatha Narayanaswamy Govt Coll Autonomous, PG & Res Dept Chem, Ponneri 601204, Tamil Nadu, India
关键词
Computational chemistry; Organic chemistry; Systems biology; Bioinformatics; Biotechnology; Biochemistry; Imidazole; Imidazolium salt; Benzoate; Protein-ligand interaction; SARS COV-2; Docking; CORONAVIRUS; DRUG; CHLOROQUINE; INHIBITION; INFECTION; EFFICACY;
D O I
10.1016/j.heliyon.2020.e05544
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The disease called severe acute respiratory syndrome (SARS) is a lifestyle intimidating viral contamination affected by a positive, single stranded novel RNA virus (COVID-2019) from the enveloped coronaviruse family. The COVID-2019 virus has affected many people, scattering promptly, and researchers are attempting to find out medicines for its effectual cure in all over the globe. Chloroquine (ChQ) and its derivatives, an older drug used for the cure of malaria, is exposed to encompass a perceptible feasibility and commendable well-being in opposition to SARS CoV-2 associated pneumonia clinical trials conducted in China. Later on, a few investigations have been directed to find and present SARS CoV-2 antiviral medications. The aim of this present work deals with the potential binding interactions of some imidazolium salts with Nsp9 (Nonstructural protein 9) RNA binding protein of SARS CoV-2.
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页数:14
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