DC subsets in positive and negative regulation of immunity

被引：121

作者：

Coquerelle, Caroline ^{[1
]}

Moser, Muriel ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Physiol Anim Lab, Dept Mol Biol, B-6041 Gosselies, Belgium

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 234卷

关键词：

dendritic cells; Th1; Th2; Th17 balance in vivo; regulation; CELLS IN-VIVO; ANTIGEN-PRESENTING CELLS; CD4(+) T-CELLS; MHC CLASS-II; PLASMACYTOID DENDRITIC CELLS; EPIDERMAL LANGERHANS CELLS; COSTIMULATORY LIGAND CD70; INDOLEAMINE 2,3-DIOXYGENASE; STEADY-STATE; LYMPH-NODES;

D O I：

10.1111/j.0105-2896.2009.00887.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since their discovery in 1973, dendritic cells (DCs) have gained strong interest from immunologists because of their unique capacity to sensitize naive T cells. There is now strong evidence that cells of the dendritic family not only control immunity but also regulate responses to self and non-self, thereby avoiding immunopathology. These two complementary functions are critical to ensure the integrity of the organism in an environment full of antigens. How DCs display these opposite functions is still intriguing. Here, we review the role of DC subsets in the regulation of T-helper responses in vivo.

引用

页码：317 / 334

页数：18

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