DC subsets in positive and negative regulation of immunity

被引：121

作者：

Coquerelle, Caroline ^{[1
]}

Moser, Muriel ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Physiol Anim Lab, Dept Mol Biol, B-6041 Gosselies, Belgium

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 234卷

关键词：

dendritic cells; Th1; Th2; Th17 balance in vivo; regulation; CELLS IN-VIVO; ANTIGEN-PRESENTING CELLS; CD4(+) T-CELLS; MHC CLASS-II; PLASMACYTOID DENDRITIC CELLS; EPIDERMAL LANGERHANS CELLS; COSTIMULATORY LIGAND CD70; INDOLEAMINE 2,3-DIOXYGENASE; STEADY-STATE; LYMPH-NODES;

D O I：

10.1111/j.0105-2896.2009.00887.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since their discovery in 1973, dendritic cells (DCs) have gained strong interest from immunologists because of their unique capacity to sensitize naive T cells. There is now strong evidence that cells of the dendritic family not only control immunity but also regulate responses to self and non-self, thereby avoiding immunopathology. These two complementary functions are critical to ensure the integrity of the organism in an environment full of antigens. How DCs display these opposite functions is still intriguing. Here, we review the role of DC subsets in the regulation of T-helper responses in vivo.

引用

页码：317 / 334

页数：18

共 136 条

[1] CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells [J].

Adler, AJ ;

Marsh, DW ;

Yochum, GS ;

Guzzo, JL ;

Nigam, A ;

Nelson, WG ;

Pardoll, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1555-1564

[2] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[3] Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming [J].

Allan, Rhys S. ;

Waithman, Jason ;

Bedoui, Sammy ;

Jones, Claerwen M. ;

Villadangos, Jose A. ;

Zhan, Yifan ;

Lew, Andrew M. ;

Shortman, Ken ;

Heath, William R. ;

Carbone, Francis R. .

IMMUNITY, 2006, 25 (01) :153-162

[4] Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells [J].

Allan, RS ;

Smith, CM ;

Belz, GT ;

van Lint, AL ;

Wakim, LM ;

Heath, WR ;

Carbone, FR .

SCIENCE, 2003, 301 (5641) :1925-1928

[5] Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts [J].

Allison, J ;

Georgiou, HM ;

Strasser, A ;

Vaux, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3943-3947

[6] Essential role for CD103 in the T cell-mediated regulation of experimental colitis [J].

Annacker, O ;

Coombes, JL ;

Malmstrom, V ;

Uhlig, HH ;

Bourne, T ;

Johansson-Lindbom, B ;

Agace, WW ;

Parker, CM ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1051-1061

[7] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].

Asselin-Paturel, C ;

Boonstra, A ;

Dalod, M ;

Durand, I ;

Yessaad, N ;

Dezutter-Dambuyant, C ;

Vicari, A ;

O'Garra, A ;

Biron, C ;

Brière, F ;

Trinchieri, G .

NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150

[8] ATP drives lamina propria TH17 cell differentiation [J].

Atarashi, Koji ;

Nishimura, Junichi ;

Shima, Tatsuichiro ;

Umesaki, Yoshinori ;

Yamamoto, Masahiro ;

Onoue, Masaharu ;

Yagita, Hideo ;

Ishii, Naoto ;

Evans, Richard ;

Honda, Kenya ;

Takeda, Kiyoshi .

NATURE, 2008, 455 (7214) :808-U10

[9] CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation [J].

Auffray, Cedric ;

Fogg, Darin K. ;

Narni-Mancinelli, Emilie ;

Senechal, Brigitte ;

Trouillet, Celine ;

Saederup, Noah ;

Leemput, Julia ;

Bigot, Karine ;

Campisi, Laura ;

Abitbol, Marc ;

Molina, Thierry ;

Charo, Israel ;

Hume, David A. ;

Cumano, Ana ;

Lauvau, Gregoire ;

Geissmann, Frederic .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (03) :595-606

[10] CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE [J].

Bailey, Samantha L. ;

Schreiner, Bettina ;

McMahon, Eileen J. ;

Miller, Stephen D. .

NATURE IMMUNOLOGY, 2007, 8 (02) :172-180

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