Low zinc status: a new risk factor for pneumonia in the elderly?

被引：93

作者：

Barnett, Junaidah B. ^{[2
,3
]}

Hamer, Davidson H. ^{[4
,5
]}

Meydani, Simin N. ^{[1
]}

机构：

[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Immunol Lab, Dept Pathol,Sackler Grad Sch Biochem Sci, Boston, MA 02111 USA

[2] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Infect Unit,Dept Publ Hlth & Family Med, Nutr Immunol Lab,Sch Med,Friedman Sch Nutr Sci &, Boston, MA 02111 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Boston Univ, Sch Med, Dept Med,Tufts Univ,Friedman Sch Nutr Sci & Polic, Nutrit Immunol Lab,Jean Mayer USDA Human Nutr Res, Boston, MA 02118 USA

[5] Boston Univ, Sch Publ Hlth, Ctr Int Hlth & Dev, Boston, MA USA

来源：

NUTRITION REVIEWS | 2010年 / 68卷 / 01期

基金：

美国国家卫生研究院; 美国农业部;

关键词：

elderly; nursing home; pneumonia; zinc; RESPIRATORY SYNCYTIAL VIRUS; COMMUNITY-ACQUIRED PNEUMONIA; NURSING-HOME RESIDENTS; RANDOMIZED CONTROLLED-TRIAL; CELL-MEDIATED-IMMUNITY; TERM-CARE FACILITY; HUMAN T-CELLS; CYTOKINE PRODUCTION; AGED MICE; VITAMIN-E;

D O I：

10.1111/j.1753-4887.2009.00253.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Low zinc status may be a risk factor for pneumonia in the elderly. This special article reviews the magnitude of the problem of pneumonia (its prevalence, morbidity, and mortality) in the elderly, pneumonia's etiology, and the dysregulation of the immune system associated with increasing age. In addition, recent evidence from the literature is presented demonstrating that low zinc status (commonly reported in the elderly) impairs immune function, decreases resistance to pathogens, and is associated with increased incidence and duration of pneumonia, increased use and duration of antimicrobial treatment, and increased overall mortality in the elderly. Inadequate stores of zinc might, therefore, be a risk factor for pneumonia in the elderly. Randomized, double-blind, controlled studies are needed to determine the efficacy of zinc supplementation as a potential low-cost intervention to reduce morbidity and mortality due to pneumonia in this vulnerable population.

引用

页码：30 / 37

页数：8

共 118 条

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