Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

被引：51

作者：

Chapla, Vanessa Mara ^{[1
]}

Zeraik, Maria Luiza ^{[1
]}

Leptokarydis, Ioanis Hcristos ^{[1
]}

Silva, Geraldo Humberto ^{[2
]}

Bolzani, Vanderlan Silva ^{[1
]}

Young, Maria Claudia M. ^{[3
]}

Pfenning, Ludwig Heinrich ^{[4
]}

Araujo, Angela Regina ^{[1
]}

机构：

[1] Univ Estadual Paulista, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ, Inst Quim,UNESP, BR-14800900 Araraquara, SP, Brazil

[2] Univ Fed Vicosa, Inst Ciencias Exatas, BR-38810000 Vicosa, MG, Brazil

[3] Nucleo Pesquisa Fisiol & Bioquim, Inst Bot, BR-04301902 Sao Paulo, Brazil

[4] Univ Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG, Brazil

来源：

MOLECULES | 2014年 / 19卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

Colletotrichum gloeosporioides; endophytic fungus; antifungal activity; CHEMICAL-SHIFTS; ACETYLCHOLINESTERASE; METABOLITES; ACID;

D O I：

10.3390/molecules191119243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl) acetic acid (6), 4-hydroxy-benzamide (7) and 2(2-hydroxyphenyl) acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin.

引用

页码：19243 / 19252

页数：10

共 21 条

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