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Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
被引:124
作者:

Brown, Nicholas G.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

VanderLinden, Ryan
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Watson, Edmond R.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Weissmann, Florian
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机构:
Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

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Wu, Kuen-Phon
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Zhang, Wei
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机构:
Univ Toronto, Donnelly Ctr Cellular & Biomol Res, 160 Coll St, Toronto, ON M5S 3E1, Canada St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Yu, Shanshan
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Mercredi, Peter Y.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Harrison, Joseph S.
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h-index: 0
机构:
Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Davidson, Iain F.
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机构:
Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Qiao, Renping
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Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Lu, Ying
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Dube, Prakash
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机构:
Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Brunner, Michael R.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Grace, Christy R. R.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Miller, Darcie J.
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Haselbach, David
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Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Jarvis, Marc A.
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Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Yamaguchi, Masaya
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Yanishevski, David
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St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Petzold, Georg
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Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Sidhu, Sachdev S.
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Univ Toronto, Donnelly Ctr Cellular & Biomol Res, 160 Coll St, Toronto, ON M5S 3E1, Canada St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Kuhlman, Brian
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Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Kirschner, Marc W.
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Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Harper, J. Wade
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Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Peters, Jan-Michael
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Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Stark, Holger
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h-index: 0
机构:
Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA

Schulman, Brenda A.
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA
机构:
[1] St Jude Childrens Res Hosp, Dept Biol Struct, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA
[3] Vienna Bioctr VBC, Res Inst Mol Pathol IMP, A-1030 Vienna, Austria
[4] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[5] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, 160 Coll St, Toronto, ON M5S 3E1, Canada
[6] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA
[7] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[8] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA
[9] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany
来源:
基金:
日本学术振兴会;
奥地利科学基金会;
关键词:
ANAPHASE-PROMOTING COMPLEX;
MITOTIC CHECKPOINT COMPLEX;
SUBSTRATE DEGRADATION;
LIGASE ACTIVITY;
CYCLIN B1;
MECHANISM;
REVEALS;
MITOSIS;
INSIGHTS;
E2;
D O I:
10.1016/j.cell.2016.05.037
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin (UB) and then achieve different forms of polyubiquitination: multiubiquitination of several sites and elongation of linkage-specific UB chains. Here, cryo-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two partner E2s, UBE2C (aka UBCH10) and UBE2S, adopt specialized catalytic architectures for these two distinct forms of polyubiquitination. The APC/C RING constrains UBE2C proximal to a substrate and simultaneously binds a substrate-linked UB to drive processive multiubiquitination. Alternatively, during UB chain elongation, the RING does not bind UBE2S but rather lures an evolving substrate-linked UB to UBE2S positioned through a cullin interaction to generate a Lys11-linked chain. Our findings define mechanisms of APC/C regulation, and establish principles by which specialized E3-E2-substrate-UB architectures control different forms of polyubiquitination.
引用
收藏
页码:1440 / 1453
页数:14
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Bao, Ju
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Davidson, Iain F.
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Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

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St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

Nourse, Amanda
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St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

Kurinov, Igor
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Cornell Univ, Dept Chem & Chem Biol, NE CAT, Argonne, IL 60439 USA St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

Peters, Jan-Michael
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Res Inst Mol Pathol IMP, A-1030 Vienna, Austria St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

Stark, Holger
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机构:
Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany
Univ Gottingen, Inst Microbiol & Genet, Dept Electron Cryomicroscopy 3D, D-37077 Gottingen, Germany St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA

Schulman, Brenda A.
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h-index: 0
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St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Struct Biol, Memphis, TN 38105 USA
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