Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy?

被引：68
作者：
Chakrabarti, S
Collingham, KE
Fegan, CD
Pillay, D
Milligan, DW [1 ]
机构：
[1] Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5SS, W Midlands, England
[2] Birmingham Heartlands Hosp, Publ Hlth Lab, Birmingham B9 5SS, W Midlands, England
来源：
BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 03期
关键词：
adenovirus; immunosuppression; donor lymphocyte infusion;
D O I：
10.1038/sj.bmt.1702508
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Adenovirus has been recognised as an important pathogen in BMT recipients, especially in patients with GVHD and those receiving T cell-depleted allografts, We report adenovirus infections from an ongoing surveillance study in four patients after a non-myeloablative transplant and their improved outcome following withdrawal of immunosuppression in two patients and donor lymphocyte infusion for relapsed disease in the others. We discuss the control of adenovirus infections following immune manipulations and the feasibility of adoptive immunotherapy for post-transplant adenovirus infections.
引用
收藏
页码：305 / 307
页数：3
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