A fluorescent probe based on tetrahydro[5]helicene for highly selective recognition of hydrogen sulfide

被引：28

作者：

Lei, Yang ^{[1
]}

Wang, Kun-Peng ^{[1
]}

Chen, Shaojin ^{[1
]}

Zhang, Qi ^{[1
]}

Hu, Zhi-Qiang ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Key Lab Ecochem Engn, Key Lab Sensor Anal Tumor Marker,Minist Educ, Qingdao 266042, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2018年 / 204卷

基金：

中国国家自然科学基金;

关键词：

Fluorescent probe; Helicene; Hydrogen sulfide; LIVING CELLS; IN-VIVO; H2S; BRAIN; MITOCHONDRIA;

D O I：

10.1016/j.saa.2018.06.066

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Endogenous hydrogen sulfide plays an important role in various physiological and pathological processes and the convenient and selective recognition of hydrogen sulfide has become a research hotspot. We designed and synthesized a tetrahydro[5]helicene and 2,4-dinitrobenzene conjugate (HD-DNP) as an effective fluorescent probe for selective detection of H2S. The selective deprotection of 2,4-dinitrophenyl ether group of HD-DNP by H2S led to a dramatic fluorescent enhancement (101-fold) at 500 nm and colorimetric change in DMSO-PBS solution. HD-DNP displays many advantages including low background without any self-fluorescence, as well as high selectivity towards common bio-thiols such as Cysteine, Homocysteine and Glutathione. The detection limit of this probe for H2S was found to be about 2.4 mu M with a wide linear range (10-70 mu M). The response mechanism of the probe with HS- is confirmed to be thiolysis of the dinitrophenyl ether induced by HS- through H-1 NMR comparison investigations. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：295 / 300

页数：6

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