A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound

被引：130

作者：

Ma, Ming ^{[1
]}

Xu, Huixiong ^{[2
]}

Chen, Hangrong ^{[1
]}

Jia, Xiaoqing ^{[1
]}

Zhang, Kun ^{[1
]}

Wang, Qi ^{[3
,4
]}

Zheng, Shuguang ^{[2
]}

Wu, Rong ^{[2
]}

Yao, Minghua ^{[2
]}

Cai, Xiaojun ^{[1
]}

Li, Faqi ^{[3
,4
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

[2] Tongji Univ, Peoples Hosp 10, Shanghai 200072, Peoples R China

[3] Chongqing Med Univ, State Key Lab Ultrasound Engn Med Cofounded Chong, Coll Biomed Engn, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Minist Sci & Technol, Coll Biomed Engn, Chongqing Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 43期

基金：

中国国家自然科学基金;

关键词：

DELIVERY; HIFU; NANOPARTICLES; MICROBUBBLES; NANOCAPSULES; LIPOSOMES; THERAPY; RELEASE; SURGERY; TUMORS;

D O I：

10.1002/adma.201402969

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.

引用

页码：7378 / 7385

页数：8

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