A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound

被引：130
作者：
Ma, Ming [1 ]
Xu, Huixiong [2 ]
Chen, Hangrong [1 ]
Jia, Xiaoqing [1 ]
Zhang, Kun [1 ]
Wang, Qi [3 ,4 ]
Zheng, Shuguang [2 ]
Wu, Rong [2 ]
Yao, Minghua [2 ]
Cai, Xiaojun [1 ]
Li, Faqi [3 ,4 ]
Shi, Jianlin [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
[2] Tongji Univ, Peoples Hosp 10, Shanghai 200072, Peoples R China
[3] Chongqing Med Univ, State Key Lab Ultrasound Engn Med Cofounded Chong, Coll Biomed Engn, Chongqing 400016, Peoples R China
[4] Chongqing Med Univ, Minist Sci & Technol, Coll Biomed Engn, Chongqing Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China
来源：
ADVANCED MATERIALS | 2014年 / 26卷 / 43期
基金：
中国国家自然科学基金;
关键词：
DELIVERY; HIFU; NANOPARTICLES; MICROBUBBLES; NANOCAPSULES; LIPOSOMES; THERAPY; RELEASE; SURGERY; TUMORS;
D O I：
10.1002/adma.201402969
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.
引用
收藏
页码：7378 / 7385
页数：8
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