The abnormal recovery cycle of somatosensory evoked potential components in children with migraine can be reversed by topiramate

被引：17

作者：

Vollono, C. ^{[1
]}

Ferraro, D. ^{[2
]}

Miliucci, R. ^{[1
]}

Vigevano, F. ^{[1
]}

Valeriani, M. ^{[1
]}

机构：

[1] Catholic Univ, Osped Pediat Bambino Gesu, Headache Ctr, Div Neurol,IRCCS, Rome, Italy

[2] Catholic Univ, Inst Neurol, Dept Neurosci, Rome, Italy

来源：

CEPHALALGIA | 2010年 / 30卷 / 01期

关键词：

Migraine; somatosensory evoked potentials; pain; children; recovery cycle; TRANSCRANIAL MAGNETIC STIMULATION; CORTICAL SPREADING DEPRESSION; ANTIEPILEPTIC DRUGS; NERVE-STIMULATION; DOUBLE-BLIND; SEP-R; EXCITABILITY; INHIBITION; HYPEREXCITABILITY; PLACEBO;

D O I：

10.1111/j.1468-2982.2009.01892.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to compare the recovery cycle of somatosensory evoked potentials (SEPs) in children with migraine without aura before and after treatment with topiramate. Eleven migraine children were studied before and after a 3-month treatment with topiramate at the average dose of 1.3 mg/kg/day. We calculated the SEP latency and amplitude modifications after paired electrical stimuli at 5, 20 and 40 ms interstimulus intervals, comparing them with a single stimulus condition assumed as baseline. In nine patients, who had a significant reduction in headache frequency after treatment, the recovery cycles of the P24 (P = 0.03) and N30 (P < 0.005) potentials were longer after than before topiramate treatment. In two migraineurs who did not show any improvement, the recovery cycles of the cortical SEP components were even shorter after treatment. Our results suggest that topiramate efficacy in paediatric migraine prophylaxis is probably related to restored cortical excitability.

引用

页码：17 / 26

页数：10

共 42 条

[1] Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura [J].

Akerman, S ;

Goadsby, PJ .

NEUROREPORT, 2005, 16 (12) :1383-1387

[2] The electrophysiology of migraine [J].

Ambrosini, A ;

Schoenen, J .

CURRENT OPINION IN NEUROLOGY, 2003, 16 (03) :327-331

[3] Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing? [J].

Ambrosini, A ;

De Pasqua, V ;

Afra, J ;

Sandor, PS ;

Schoenen, J .

NEUROSCIENCE LETTERS, 2001, 306 (1-2) :132-134

[4] Electrophysiological response patterns ofprimary sensory cortices in migraine [J].

Ambrosini A. ;

Schoenen J. .

The Journal of Headache and Pain, 2006, 7 (6) :377-388

[5] Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness [J].

Aurora, SK ;

Barrodale, P ;

Chronicle, EP ;

Mulleners, WM .

HEADACHE, 2005, 45 (05) :546-552

[6] Suppression of cortical spreading depression in migraine prophylaxis [J].

Ayata, C ;

Jin, HW ;

Kudo, C ;

Dalkara, T ;

Moskowitz, MA .

ANNALS OF NEUROLOGY, 2006, 59 (04) :652-661

[7] Effects of repetitive transcranial magnetic stimulation on visual evoked potentials in migraine [J].

Bohotin, V ;

Fumal, A ;

Vandenheede, M ;

Gérard, P ;

Bohotin, C ;

de Noordhout, AM ;

Schoenen, J .

BRAIN, 2002, 125 :912-922

[8] Facilitatory effects of 1 Hz rTMS in motor cortex of patients affected by migraine with aura [J].

Brighina, F ;

Giglia, G ;

Scalia, S ;

Francolini, M ;

Palermo, A ;

Fierro, B .

EXPERIMENTAL BRAIN RESEARCH, 2005, 161 (01) :34-38

[9]

Coppola G, 2007, Cephalalgia, V27, P1427, DOI 10.1111/j.1468-2982.2007.01500.x

[10] Central nervous system excitability in migraine: Who is right? [J].

de Tommaso, M .

PAIN, 2005, 118 (1-2) :1-2

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