Association study of the ABCA7 rs37 52246 polymorphism in Alzheimer's disease

被引：9

作者：

Feher, Agnes ^{[1
]}

Juhasz, Anna ^{[1
]}

Pakaski, Magdolna ^{[1
]}

Janka, Zoltan ^{[1
]}

Kalman, Janos ^{[1
]}

机构：

[1] Univ Szeged, Dept Psychiat, 57 Kalvaria Ave, H-6724 Szeged, Hungary

来源：

PSYCHIATRY RESEARCH | 2019年 / 279卷

关键词：

Alzheimer's disease; ABCA7; APOE; Association study; rs3752246; COMMON VARIANTS; EPHA1; CD2AP; CD33;

D O I：

10.1016/j.psychres.2019.01.081

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (p = 0.054). In line with the previous results in other populations, the G allele carriers had an increased risk for developing AD considering C/C genotype as reference category.

引用

页码：376 / 377

页数：2

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