SYNTHESIS OF NEW AZOLE AND AZINE SYSTEMS BASED ON CHROMENO[3,4-c]PYRROLE-3,4-DIONE AND INVESTIGATION OF THEIR CYTOTOXIC ACTIVITY

被引：12
作者：
El Azab, Islam H. [1 ]
Aly, Mohamed R. E. [1 ,2 ]
Gobouri, Adil A. [1 ]
机构：
[1] Taif Univ, Chem Dept, Fac Sci, POB 888, At Taif 21974, Saudi Arabia
[2] Port Said Univ, Fac Sci, Chem Dept, Port Said 42522, Egypt
来源：
HETEROCYCLES | 2017年 / 94卷 / 08期
关键词：
MICROWAVE-ASSISTED SYNTHESIS; ONE-POT; BIOLOGICAL-ACTIVITY; DERIVATIVES; ANTIBACTERIAL; BENZIMIDAZOLE; ANTITUMOR;
D O I：
10.3987/COM-17-13727
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel series of 9-substituted-chromeno[4',3':3,4]pyrrolo[2,1-c]-[1,2,4]triazole-6,7-diones (4), chromeno [4',3':3,4]pyrrolo [1,2-d]tetrazole-6,7-dione (5), 9-phenyl-6H- chromeno [4',3':3,4]pyrrolo[2,1-c][1,2,4]triazine-6,7 (11H)-dione (8), chromeno [4',3':3,4]pyrrolo [2,1-c][1,2,4]triazole-6,7,9(10H)-trione (10), (3,5-substituted-pyrazol-1-yl)chromeno[3,4-c]pyrrole-3,4-dione (15-19) and thiazole derivatives (28-37) were synthesized using 1-hydrazinylchromeno[3,4-c]-pyrrole-3,4-dione (2) as a precursor. The newly synthesized compounds were characterized and evaluated for their cytotoxic activity.
引用
收藏
页码：1456 / 1478
页数：23
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