SYNTHESIS OF NEW AZOLE AND AZINE SYSTEMS BASED ON CHROMENO[3,4-c]PYRROLE-3,4-DIONE AND INVESTIGATION OF THEIR CYTOTOXIC ACTIVITY

被引：12

作者：

El Azab, Islam H. ^{[1
]}

Aly, Mohamed R. E. ^{[1
,2
]}

Gobouri, Adil A. ^{[1
]}

机构：

[1] Taif Univ, Chem Dept, Fac Sci, POB 888, At Taif 21974, Saudi Arabia

[2] Port Said Univ, Fac Sci, Chem Dept, Port Said 42522, Egypt

来源：

HETEROCYCLES | 2017年 / 94卷 / 08期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; ONE-POT; BIOLOGICAL-ACTIVITY; DERIVATIVES; ANTIBACTERIAL; BENZIMIDAZOLE; ANTITUMOR;

D O I：

10.3987/COM-17-13727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of 9-substituted-chromeno[4',3':3,4]pyrrolo[2,1-c]-[1,2,4]triazole-6,7-diones (4), chromeno [4',3':3,4]pyrrolo [1,2-d]tetrazole-6,7-dione (5), 9-phenyl-6H- chromeno [4',3':3,4]pyrrolo[2,1-c][1,2,4]triazine-6,7 (11H)-dione (8), chromeno [4',3':3,4]pyrrolo [2,1-c][1,2,4]triazole-6,7,9(10H)-trione (10), (3,5-substituted-pyrazol-1-yl)chromeno[3,4-c]pyrrole-3,4-dione (15-19) and thiazole derivatives (28-37) were synthesized using 1-hydrazinylchromeno[3,4-c]-pyrrole-3,4-dione (2) as a precursor. The newly synthesized compounds were characterized and evaluated for their cytotoxic activity.

引用

页码：1456 / 1478

页数：23

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