Alveolar macrophages in chronic obstructive pulmonary disease (COPD)

被引：0

作者：

Barnes, PJ ^{[1
]}

机构：

[1] Univ London, Natl Heart & Lung Inst, Sch Med, London SW3 6LY, England

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2004年 / 50卷

关键词：

inflammation; protease; cytokine; alveolar macrophage; phagocytosis; chemokine;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alveolar macrophages play a critical role as orchestrators of inflammation in chronic obstructive pulmonary disease (COPD). The numbers of alveolar macrophages are markedly increased in the lungs of patients with COPD as a result of increased recruitment, proliferation and survival. Alveolar macrophages secrete many inflammatory mediators, oxidants, proteins and proteinases in response to cigarette smoke extract and other stimuli. In COPD there is amplified secretion of these inflammatory products which may be related to defective histone deacetylase-2, which may also account for the steroid resistance of these cells in COPD patients. There are several novel therapeutic strategies targeted at macrophages.

引用

页码：627 / 637

页数：11

共 94 条

[11] Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations [J].

Caramori, G ;

Romagnoli, M ;

Casolari, P ;

Bellettato, C ;

Casoni, G ;

Boschetto, P ;

Chung, KF ;

Barnes, PJ ;

Adcock, IM ;

Ciaccia, A ;

Fabbri, LM ;

Papi, A .

THORAX, 2003, 58 (04) :348-351

[12] Both Erk and p38 kinases are necessary for cytokine gene transcription [J].

Carter, AB ;

Monick, MM ;

Hunninghake, GW .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (04) :751-758

[13] ACCUMULATION OF LANGERHANS CELLS ON THE EPITHELIAL SURFACE OF THE LOWER RESPIRATORY-TRACT IN NORMAL SUBJECTS IN ASSOCIATION WITH CIGARETTE-SMOKING [J].

CASOLARO, MA ;

BERNAUDIN, JF ;

SALTINI, C ;

FERRANS, VJ ;

CRYSTAL, RG .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (02) :406-411

[14] Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release [J].

Churg, A ;

Wang, RD ;

Tai, H ;

Wang, XS ;

Xie, CS ;

Dai, J ;

Shapiro, SD ;

Wright, JL .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (08) :1083-1089

[15] Diverse cellular TGF-beta(1) and TGF-beta(3) gene expression in normal human and murine lung [J].

Coker, RK ;

Laurent, GJ ;

Shahzeidi, S ;

HernandezRodriguez, NA ;

Pantelidis, P ;

duBois, RM ;

Jeffery, PK ;

McAnulty, RJ .

EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (12) :2501-2507

[16]

CULPITT S, 1997, AM J RESP CRIT CARE, V157, pA797

[17] Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease [J].

Culpitt, SV ;

Maziak, W ;

Loukidis, S ;

Nightingale, JA ;

Matthews, JL ;

Barnes, PJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (05) :1635-1639

[18] Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD [J].

Culpitt, SV ;

Rogers, DF ;

Fenwick, PS ;

Shah, P ;

De Matos, C ;

Russell, REK ;

Barnes, PJ ;

Donnelly, LE .

THORAX, 2003, 58 (11) :942-946

[19] Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease [J].

Culpitt, SV ;

Rogers, DF ;

Shah, P ;

De Matos, C ;

Russell, REK ;

Donnelly, LE ;

Barnes, PJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (01) :24-31

[20] Transforming growth factor β1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease [J].

de Boer, WI ;

van Schadewijk, A ;

Sont, JK ;

Sharma, HS ;

Stolk, J ;

Hiemstra, PS ;

van Krieken, JHJM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (06) :1951-1957

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