Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

被引：36

作者：

Burguete, M. Isabel ^{[1
,2
]}

Galindo, Francisco ^{[1
,2
]}

Gavara, Raquel ^{[1
,2
]}

Luis, Santiago V. ^{[1
,2
]}

Moreno, Miguel ^{[3
]}

Thomas, Paul ^{[4
]}

Russell, David A. ^{[3
]}

机构：

[1] UAMOA, Dept Quim Inorgan & Organ, Av Sos Baynat S-N, Castellon de La Plana 12071, Spain

[2] Univ Jaume 1, CSIC, Castellon de La Plana 12071, Spain

[3] Univ East Anglia, Sch Chem Sci & Pharm, Norwich NR4 7TJ, Norfolk, England

[4] Univ East Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2009年 / 8卷 / 01期

关键词：

MODIFIED SILICA NANOPARTICLES; MACROPOROUS POLYMER; ROSE-BENGAL; THERAPY; CATALYSTS; SENSITIZERS; IMMOBILIZATION; MORPHOLOGY; SEPARATION; APOPTOSIS;

D O I：

10.1039/b810921d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photogeneration of singlet oxygen (O-1(2)) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

引用

页码：37 / 44

页数：8

共 59 条

[1] Recent progress in the immobilization of catalysts for selective oxidation in the liquid phase [J].