Current Progress on Biosensors and Point-of-Care Devices for Sepsis Diagnosis

Sepsis is a life-threatening syndrome that remains one of the major causes of mortality in critically ill patients worldwide. Early sepsis diagnosis is vital to prevent the disease progress and increase recovery chances through an appropriate antibiotic treatment. The need for specific and fast diagnosis has resulted to the development of bioanalytical approaches that could be used at the point-of-care (PoC). To this direction, different types of biosensors have been developed for detection and quantitative determination of one or more biomarkers related to sepsis diagnosis and prognosis. In this review, we provide an overview of the recent advancements in biosensors and PoC systems for sepsis diagnosis as well as a short introduction about the biomarkers currently implemented in sepsis diagnosis/prognosis. In addition, the conventional methods for sepsis diagnosis are presented in brief and a comparison with biosensors and point-of-care systems is provided.