Partial reduction of electron-deficient pyridines

被引：34

作者：

Donohoe, TJ

McRiner, AJ

Sheldrake, P

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

[2] SmithKline Beecham Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 24期

关键词：

D O I：

10.1021/ol0065930

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The partial reduction of electron-deficient pyridines is described herein. Mono- and disubstituted pyridines can be transformed into functionalized dihydropyridines using either Birch reduction conditions or sodium/naphthalene in THF. The compounds formed by these high-yielding reductive alkylation protocols have potential as synthetic intermediates, and we have shown that bicycle compounds containing 6,5, 6,6, and 6,7 ring systems can be prepared in one step via a base-promoted cylization.

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页码：3861 / 3863

页数：3

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