Rearrangements of NTRK1 gene in papillary thyroid carcinoma

被引：136
作者：
Greco, A. [1 ]
Miranda, C. [1 ]
Pierotti, M. A. [2 ]
机构：
[1] Ist Nazl Tumori, Fdn IRCCS, Dept Expt Oncol & Lab, Operat Unit Mol Mech Canc Growth & Progress 3, I-20133 Milan, Italy
[2] Ist Nazl Tumori, Fdn IRCCS, Sci Directorate, I-20133 Milan, Italy
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 321卷 / 01期
关键词：
NTRK1; Gene rearrangement; Papillary thyroid tumor; ONCOGENES; RADIATION; GROWTH; TUMORS; RET;
D O I：
10.1016/j.mce.2009.10.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of IRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of IRK oncoproteins. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：44 / 49
页数：6
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