SYNTHESIS AND PROPERTIES OF PHOSPHORUS-CONTAINING PSEUDO-POLY(AMINO ACID)S OF POLYESTER TYPE BASED ON N-DERIVATIVES OF GLUTAMINIC ACID

被引：3

作者：

Stasiuk, Anna ^{[1
]}

Fihurka, Nataliia ^{[1
]}

Vlizlo, Vasyl ^{[2
]}

Prychak, Sofiia ^{[1
]}

Ostapiv, Dmytro ^{[3
]}

Varvarenko, Serhii ^{[1
]}

Samaryk, Volodymyr ^{[1
]}

机构：

[1] Lviv Polytech Natl Univ, 12 S Bandery St, UA-79013 Lvov, Ukraine

[2] Stepan Gzhytskyi Natl Univ Vet Med & Biotechnol, 50 Pekarska St, UA-79010 Lvov, Ukraine

[3] Inst Anim Biol NAAS, 38 V Stusa St, UA-79034 Lvov, Ukraine

来源：

CHEMISTRY & CHEMICAL TECHNOLOGY | 2022年 / 16卷 / 01期

关键词：

poly(phosphoester)s; pseudo-poly(amino acid)s; glutamic acid; polyethylene glycol; Steglich reaction; drug delivery; BIOMEDICAL APPLICATIONS; EPOXY-RESIN; POLYMERS; OLIGOMERS; DIOLS;

D O I：

10.23939/chcht16.01.051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(phosphoeter)s (PPE)s are a class of polymers possessing a high chemical functionality and biodegradability. Novel, glutamic acid based poly (phosphoeter)s were synthesized by the Steglich reaction. The developed synthetic approach allows controlling the composition and the structure of PPEs, and therefore their physical and colloidal properties. The studies on solubilization and cytotoxicity in vitro proved the potential of PPEs for drug delivery applications.

引用

页码：51 / 58

页数：8

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