A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

被引：282

作者：

Li, Zheng ^{[1
,2
]}

Jiang, Hong ^{[3
]}

Xu, Changmou ^{[1
]}

Gu, Liwei ^{[1
]}

机构：

[1] Univ Florida, Inst Food & Agr Sci, Food Sci & Human Nutr Dept, Gainesville, FL 32611 USA

[2] Huangshan Kehong Bioflavors CO Ltd, Huangshan 245200, Anhui, Peoples R China

[3] Univ Louisville, James Graham Brown Canc Ctr, Dept Microbiol & Immunol, Louisville, KY 40202 USA

来源：

FOOD HYDROCOLLOIDS | 2015年 / 43卷

关键词：

Phenolic phytochemicals; Nanoparticles; Absorption; Bioavailability; Endocytosis; EPITHELIAL TIGHT JUNCTIONS; LOW-DENSITY-LIPOPROTEIN; GREEN TEA POLYPHENOL; RED WINE; SOY ISOFLAVONES; CELLULAR UPTAKE; IN-VITRO; ANTIOXIDANT PROPERTIES; INTESTINAL-ABSORPTION; GELATIN NANOPARTICLES;

D O I：

10.1016/j.foodhyd.2014.05.010

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phenolic phytochemicals have been of particular interests in food and pharmaceutical fields because they have potential to reduce the incidences of coronary heart disease, diabetes, cancers, and other chronic diseases. However, extremely low absorption rate of phenolic phytochemicals restricts their bioactivity in vivo. Such low absorption and bioavailability are due to their low water solubility, poor stability, passive diffusion, and active efflux in the gastrointestinal tract. Nanoparticle delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds. This review explains absorption barriers of phenolic phytochemicals in the gastrointestinal tract. Nanoparticles delivery systems are emphasized regarding fabrication methods and their potential benefits on phenolic phytochemical absorption. Particularly, absorption mechanisms of nanoparticles by epithelial cells and biodistribution of nanoparticles after absorption are mainly discussed. Moreover, the potential challenges of nanoparticles as delivery system for phenolic phytochemicals in the gastrointestinal tract are also discussed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：153 / 164

页数：12

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