A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals

被引:281
作者
Li, Zheng [1 ,2 ]
Jiang, Hong [3 ]
Xu, Changmou [1 ]
Gu, Liwei [1 ]
机构
[1] Univ Florida, Inst Food & Agr Sci, Food Sci & Human Nutr Dept, Gainesville, FL 32611 USA
[2] Huangshan Kehong Bioflavors CO Ltd, Huangshan 245200, Anhui, Peoples R China
[3] Univ Louisville, James Graham Brown Canc Ctr, Dept Microbiol & Immunol, Louisville, KY 40202 USA
关键词
Phenolic phytochemicals; Nanoparticles; Absorption; Bioavailability; Endocytosis; EPITHELIAL TIGHT JUNCTIONS; LOW-DENSITY-LIPOPROTEIN; GREEN TEA POLYPHENOL; RED WINE; SOY ISOFLAVONES; CELLULAR UPTAKE; IN-VITRO; ANTIOXIDANT PROPERTIES; INTESTINAL-ABSORPTION; GELATIN NANOPARTICLES;
D O I
10.1016/j.foodhyd.2014.05.010
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Phenolic phytochemicals have been of particular interests in food and pharmaceutical fields because they have potential to reduce the incidences of coronary heart disease, diabetes, cancers, and other chronic diseases. However, extremely low absorption rate of phenolic phytochemicals restricts their bioactivity in vivo. Such low absorption and bioavailability are due to their low water solubility, poor stability, passive diffusion, and active efflux in the gastrointestinal tract. Nanoparticle delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds. This review explains absorption barriers of phenolic phytochemicals in the gastrointestinal tract. Nanoparticles delivery systems are emphasized regarding fabrication methods and their potential benefits on phenolic phytochemical absorption. Particularly, absorption mechanisms of nanoparticles by epithelial cells and biodistribution of nanoparticles after absorption are mainly discussed. Moreover, the potential challenges of nanoparticles as delivery system for phenolic phytochemicals in the gastrointestinal tract are also discussed. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:153 / 164
页数:12
相关论文
共 196 条
[1]   Bioavailability of nanoparticles in nutrient and nutraceutical delivery [J].
Acosta, Edgar .
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2009, 14 (01) :3-15
[2]   Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis [J].
Afaq, Farrukh ;
Syed, Deeba N. ;
Malik, Arshi ;
Hadi, Naghma ;
Sarfaraz, Sami ;
Kweon, Mee-Hyang ;
Khan, Naghma ;
Abu Zaid, Mohammad ;
Mukhtar, Hasan .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (01) :222-232
[3]   RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (Retracted article. See vol. 102, pg. 143, 2016) [J].
Anand, Preetha ;
Nair, Hareesh B. ;
Sung, Bokyung ;
Kunnumakkara, Ajaikumar B. ;
Yadav, Vivek R. ;
Tekmal, Rajeshwar R. ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2010, 79 (03) :330-338
[4]  
[Anonymous], 2000, BIOCHEM PHARMACOL
[5]   Flavonoids of leguminous plants: Structure, biological activity, and biosynthesis [J].
Aoki, T ;
Akashi, T ;
Ayabe, S .
JOURNAL OF PLANT RESEARCH, 2000, 113 (1112) :475-488
[6]   Procyanidin Dimers A1, A2, and B2 Are Absorbed without Conjugation or Methylation from the Small Intestine of Rats [J].
Appeldoorn, Maaike M. ;
Vincken, Jean-Paul ;
Gruppen, Harry ;
Hollman, Peter C. H. .
JOURNAL OF NUTRITION, 2009, 139 (08) :1469-1473
[7]   COPIGMENTATION OF ANTHOCYANINS IN PLANT-TISSUES AND ITS EFFECT ON COLOR [J].
ASEN, S ;
STEWART, RN ;
NORRIS, KH .
PHYTOCHEMISTRY, 1972, 11 (03) :1139-&
[8]   Albumin stabilizes (-)-epigallocatechin gallate in human serum: Binding capacity and antioxidant property [J].
Bae, Min-Jung ;
Ishii, Takeshi ;
Minoda, Kanako ;
Kawada, Yukiko ;
Ichikawa, Tatsuya ;
Mori, Taiki ;
Kamihira, Miya ;
Nakayama, Tsutomu .
MOLECULAR NUTRITION & FOOD RESEARCH, 2009, 53 (06) :709-715
[9]   General method for extraction of blueberry anthocyanins and identification using high performance liquid chromatography-electrospray ionization-ion trap-time of flight-mass spectrometry [J].
Barnes, Jeremy S. ;
Nguyen, Hien P. ;
Shen, Sijia ;
Schug, Kevin A. .
JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (23) :4728-4735
[10]   Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport [J].
Behrens, I ;
Pena, AIV ;
Alonso, MJ ;
Kissel, T .
PHARMACEUTICAL RESEARCH, 2002, 19 (08) :1185-1193