Early differential diagnosis between Alzheimer's disease and dementia with Lewy bodies: Comparison between 18F-FDG PET and 123I-IMP SPECT

被引：16
作者：
Chiba, Yuhei [1 ,2 ,3 ]
Iseki, Eizo [1 ,2 ]
Fujishiro, Hiroshige [1 ,2 ,4 ]
Ota, Kazumi [1 ]
Kasanuki, Koji [1 ,2 ]
Suzuki, Masaru [1 ]
Hirayasu, Yoshio [3 ]
Arai, Heii [2 ]
Sato, Kiyoshi [1 ]
机构：
[1] Juntendo Univ, Sch Med, Juntendo Tokyo Koto Geriatr Med Ctr, PET CT Dementia Res Ctr,Koto Ku, 3-3-20 Shinsuna, Tokyo 1360075, Japan
[2] Juntendo Univ, Dept Psychiat, Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan
[3] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan
[4] Nagoya Univ, Dept Psychiat, Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2016年 / 249卷
关键词：
Early diagnosis; DLB; AD; MCI; FDG PET; IMP SPECT; MILD COGNITIVE IMPAIRMENT; SLEEP BEHAVIOR DISORDER; BRAIN PERFUSION SPECT; FDG-PET; GLUCOSE HYPOMETABOLISM; PRODROMAL DEMENTIA; FOLLOW-UP; METABOLISM; ASSOCIATION; FEATURES;
D O I：
10.1016/j.pscychresns.2015.12.007
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Both F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and I-123-iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) have been used for the differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Less information is available, however, regarding the differential diagnosis of mild cognitive impairment (MCI) due to AD and MCI due to DLB. We examined nine AD patients (AD group), nine DLB patients (DLB group), eight MCI due to AD patients (MCI-AD group), and nine MCI due to DLB patients (MCI-DLB group) with FDG PET and IMP SPECT using a well-characterized normal database and a stereotactic extraction estimation method. In the AD and DLB groups, receiver operating characteristic (ROC) analysis in the occipital regions showed significant accuracy of both FDG PET and IMP SPECT for the differential diagnosis. In the MCI-AD and MCI-DLB groups, ROC analysis showed significant accuracy of only FDG PET for the differential diagnosis. Both FDG PET and IMP SPECT would be useful for the differential diagnosis between AD and DLB. For the differential diagnosis of MCI-AD versus MCI-DLB, FDG PET would be more useful than IMP SPECT. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：105 / 112
页数：8
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