Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line

被引：274

作者：

Min, Y.-D.

Choi, C.-H.

Bark, H.

Son, H.-Y.

Park, H.-H.

Lee, S.

Park, J.-W.

Park, E.-K.

Shin, H.-I.

Kim, S.-H. ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Taegu 700422, South Korea

[2] Chosun Univ, Sch Med, Dept Surg, Kwangju 501759, South Korea

[3] Chosun Univ, Sch Med, Dept Pharmacol, Kwangju 501759, South Korea

[4] Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Taegu 700422, South Korea

[5] Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Taegu 700422, South Korea

来源：

INFLAMMATION RESEARCH | 2007年 / 56卷 / 05期

关键词：

quercetin; mast cell; allergic inflammation; pro-inflammatory cytokine;

D O I：

10.1007/s00011-007-6172-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective and design: Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1. Methods: HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI). Results: Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-kappa B and p38 mitogen-activated protein kinase. Conclusion: Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.

引用

页码：210 / 215

页数：6

共 38 条

[1] Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1) [J].