Nickel-Catalyzed Guerbet Type Reaction: C-Alkylation of Secondary Alcohols via Double (de)Hydrogenation

被引：57

作者：

Babu, Reshma ^{[1
]}

Subaramanian, Murugan ^{[1
]}

Midya, Siba P. ^{[1
]}

Balaraman, Ekambaram ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Tirupati, Dept Chem, Tirupati 517507, Andhra Pradesh, India

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 09期

关键词：

N-HETEROCYCLIC CARBENE; CROSS-COUPLING REACTIONS; BETA-ALKYLATION; ALPHA-ALKYLATION; BORROWING HYDROGEN; METHYL KETONES; IRIDIUM; COMPLEXES;

D O I：

10.1021/acs.orglett.1c00782

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acceptorless double dehydrogenative cross-coupling of secondary and primary alcohols under nickel catalysis is reported. This Guerbet type reaction provides an atom- and a step-economical method for the C-alkylation of secondary alcohols under mild, benign conditions. A broad range of substrates including aromatic, cyclic, acyclic, and aliphatic alcohols was well tolerated. Interestingly, the C-alkylation of cholesterol derivatives and the double C-alkylation of cyclopentanol with various alcohols were also demonstrated.

引用

页码：3320 / 3325

页数：6

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