Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits

被引：112

作者：

Sharifi-Rad, Javad ^{[1
,2
]}

Dey, Abhijit ^{[3
]}

Koirala, Niranjan ^{[4
]}

Shaheen, Shabnum ^{[5
]}

El Omari, Nasreddine ^{[6
]}

Salehi, Bahare ^{[7
]}

Goloshvili, Tamar ^{[8
]}

Cirone Silva, Nathalia Cristina ^{[9
]}

Bouyahya, Abdelhakim ^{[10
]}

Vitalini, Sara ^{[11
]}

Varoni, Elena M. ^{[12
]}

Martorell, Miquel ^{[13
,14
]}

Abdolshahi, Anna ^{[15
]}

Docea, Anca Oana ^{[16
]}

Iriti, Marcello ^{[11
]}

Calina, Daniela ^{[17
]}

Les, Francisco ^{[18
,19
]}

Lopez, Victor ^{[18
,19
]}

Caruntu, Constantin ^{[20
,21
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran

[2] Univ Azuay, Fac Med, Cuenca, Ecuador

[3] Presidency Univ, Dept Life Sci, Kolkata, India

[4] Dr Koirala Res Inst Biotechnol & Biodivers, Dept Nat Prod Drugs Discovery, Kathmandu, Nepal

[5] Women Univ, Lahore Coll, Dept Bot, Lahore, Pakistan

[6] Mohammed V Univ Rabat, Fac Med & Pharm, Lab Histol Embryol & Cytogenet, Rabat, Morocco

[7] Shahid Beheshti Univ Med Sci, Med Eth & Law Res Ctr, Tehran, Iran

[8] Ilia State Univ, Inst Bot Plant Physiol & Genet Resources, Tbilisi, Georgia

[9] Univ Campinas UNICAMP, Fac Food Engn FEA, Dept Food Sci, Campinas, Brazil

[10] Mohammed V Univ Rabat, Fac Med & Pharm, Genom Ctr Human Pathol, Lab Human Pathol Biol,Fac Sci, Rabat, Morocco

[11] Milan State Univ, Dept Agr & Environm Sci, Milan, Italy

[12] Milan State Univ, Dept Biomed Surg & Dent Sci, Milan, Italy

[13] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile

[14] Univ Concepcion, UDT, Unidad Desarrollo Tecnol, Concepcion, Chile

[15] Semnan Univ Med Sci, Food Safety Res Ctr Salt, Semnan, Iran

[16] Univ Med & Pharm Craiova, Dept Toxicol, Craiova, Romania

[17] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova, Romania

[18] Univ San Jorge, Fac Hlth Sci, Dept Pharm, Zaragoza, Spain

[19] Univ Zaragoza, CITA, Inst Agroalimentario Aragon IA2, Zaragoza, Spain

[20] Carol Davila Univ Med & Pharm, Dept Physiol, Bucharest, Romania

[21] Prof NC Paulescu Natl Inst Diabet Nutr & Metab Di, Dept Dermatol, Bucharest, Romania

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

Ciannamomum spp; phytochemistry; Pharmacology; mechanisms of action; clinical trials; Toxicological data; POLYCYSTIC-OVARY-SYNDROME; OREGANO ESSENTIAL OIL; PLANT ESSENTIAL OILS; LEAF ESSENTIAL OILS; KAPPA-B ACTIVATION; ANTIBACTERIAL ACTIVITY; IN-VITRO; DIABETES-MELLITUS; ESCHERICHIA-COLI; CASSIA BARK;

D O I：

10.3389/fphar.2021.600139

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.

引用

页数：27

共 235 条

[21]

Bedigian D., 2005, ECON BOT, V3659, P93, DOI [10.1663/0013-0001(2005)059, DOI 10.1663/0013-0001(2005)059]

[22] Constituents of the essential oils of Cinnamomum sintoc Blume from a mountain forest of Peninsular Malaysia [J].