Evaluation of the Antiprotozoal Activity of Neo-clerodane Type Diterpenes from Salvia polystachya against Entamoeba histolytica and Giardia lamblia

被引：21

作者：

Calzada, Fernando ^{[1
]}

Yepez-Mulia, Lilian ^{[2
]}

Tapia-Contreras, Amparo ^{[2
]}

Bautista, Elihu ^{[3
]}

Maldonado, Emma ^{[3
]}

Ortega, Alfredo ^{[3
]}

机构：

[1] UMAF Hosp Pediat, Unidad Invest Med Farmacol Prod Nat, Piso CORCE 2, IMSS,Ctr Med Nacl Siglo 21, Mexico City 06725, DF, Mexico

[2] UMAF Hosp Pediat, Unidad Invest Med Enfermedades Infecciosas & Para, IMSS, Ctr Med Nacl Siglo 21, Mexico City 06725, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 05期

关键词：

Salvia polystachya; neo-clerodane diterpenes; linearolactone; antiprotozoal activity; Entanweba histolytica; Giardia lamblia; MEXICAN TRADITIONAL MEDICINE; ANTIGIARDIAL ACTIVITY; CLERODANE DITERPENOIDS; PLANTS; DIARRHEA; FLAVONOIDS;

D O I：

10.1002/ptr.2938

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chia (Salvia polystachya Ort., Lamiaceae) is frequently used in Mexican traditional medicine to treat dysentery. In this study the main neo-clerodane diterpenes (polystachynes A, B and D, as well as linearolactone) were isolated from the aerial parts of chia, and their antiprotozoal activities toward Entamoeba histolytica and Giardia lamblia trophozoites were evaluated in vitro. Linearolactone was the most potent antiamoebic and antigiardial compound with IC(50) values of 22.9 mu M for E. histolytica and 28.2 mu M for G. lamblia. Polystachynes A, B and D, showed moderate antiprotozoal activity against both protozoans with IC(50) values ranging from 1.17.0 to 160.6 mu M for E. histolytica and from 107.5 to 134.7 mu M for G. lamblia. These data suggest that linearolactone may play an important role in the antidiarrhoeal activity of S. polystachya. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：662 / 665

页数：4

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