TTC-Pluronic 3D radiochromic gel dosimetry of ionizing radiation

被引:39
|
作者
Kozicki, Marek [1 ,2 ]
Kwiatos, Klaudia [1 ]
Kadlubowski, Slawomir [3 ]
Dudek, Mariusz [4 ]
机构
[1] Lodz Univ Technol, Dept Man Made Fibres, Lodz, Poland
[2] GeVero Co, Lodz, Poland
[3] Lodz Univ Technol, Inst Appl Radiat Chem, Lodz, Poland
[4] Lodz Univ Technol, Inst Mat Sci & Engn, Lodz, Poland
来源
PHYSICS IN MEDICINE AND BIOLOGY | 2017年 / 62卷 / 14期
关键词
2; 3; 5-triphenyltetrazolium chloride; Pluronic; 3D radiochromic gel; 3D dosimetry; radiotherapy dosimetry; ionising radiation; leucomalachite green; NITRO BLUE TETRAZOLIUM; HIGH-DOSE DOSIMETRY; POLYMER GELS; AQUEOUS-SOLUTIONS; COMPUTED-TOMOGRAPHY; HYDRATED ELECTRONS; HYDROXYL RADICALS; PULSE-RADIOLYSIS; ACTIVE COMPOUND; OPTICAL SCANNER;
D O I
10.1088/1361-6560/aa77eb
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This work reports the first results obtained using a new 3D radiochromic gel dosimeter. The dosimeter is an aqueous physical gel matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127, PEO-PPO-PEO) doped with a representative of tetrazolium salts, 2, 3, 5-triphenyltetrazolium chloride (TTC). There were several reasons for the choice of Pluronic as a gel forming substrate: (i) the high degree of transparency and colourlessness; (ii) the possibility of gel dosimeter preparation at both high and low temperatures due to the phase behaviour of Pluronic; (iii) the broad temperature range over which the TTC-Pluronic dosimeter is stable; and (iv) the non-toxicity of Pluronic. A reason for the choice of TTC was its ionising radiation-induced transformation to water-insoluble formazan, which was assumed to impact beneficially on the spatial stability of the dose distribution. If irradiated, the TTC-Pluronic gels become red but transparent in the irradiated part, while the non-irradiated part remains crystal clear. The best obtained composition is characterised by <4 Gy dose threshold, a dose sensitivity of 0.00231 (Gy x cm)(-1), a large linear dose range of >500 Gy and a dynamic dose response much greater than 500 Gy (7.5% TTC, 25% Pluronic F-127, 50 mmol dm(-3) tetrakis). Temporal and spatial stability studies revealed that the TTC-Pluronic gels (7.5% TTC, 25% Pluronic F-127) were stable for more than one week. The addition of compounds boosting the gels' dose performance caused deterioration of the gels' temporal stability but did not impact the stability of the 3D dose distribution. The proposed method of preparation allows for the repeatable manufacture of the gels. There were no differences observed between gels irradiated fractionally and non-fractionally. The TTC-Pluronic dose response might be affected by the radiation source dose rate-this, however, requires further examination.
引用
收藏
页码:5668 / 5690
页数:23
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