Role of Heat Shock Proteins in Immune Modulation in Malaria

被引：2

作者：

Zininga, Tawanda ^{[1
]}

Boettger, Evelyn ^{[2
]}

Multhoff, Gabriele ^{[3
,4
]}

机构：

[1] Stellenbosch Univ, Dept Biochem, Stellenbosch, South Africa

[2] Univ Tubingen, Inst Trop Med, Tubingen, Germany

[3] Tech Univ Munich, TranslaTUM, Klinikum Rechts Isar, Klin & Poliklin Strahlentherapie & Radiol Onkol, Munich, Germany

[4] Tech Univ Munich, TranslaTUM, Cent Inst Translat Canc Res, Munich, Germany

来源：

HEAT SHOCK PROTEINS OF MALARIA, 2ND EDITION | 2021年 / 1340卷

关键词：

Parasite heat shock protein; Granzyme B; Natural killer cell; Immunotherapy; Eryptosis; Infected erythrocyte; NATURAL-KILLER-CELLS; PLASMODIUM-FALCIPARUM; SQUIRREL-MONKEY; GRANZYME-B; T-CELLS; HSP70; CHAPERONE; MEMBRANE; STRESS; HEAT-SHOCK-PROTEIN-70;

D O I：

10.1007/978-3-030-78397-6_7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Malaria is one of the major parasitic killer diseases worldwide. Severe cases of malaria are mostly in children under the age of 5 years due to their naive immune system and in pregnant women with weakened immune responses. Inflammatory immune responses against the parasite involve complement activation as well as the antibody and effector cell-mediated immune system. However, after an infection with Plasmodium falciparum (P. falciparum), the most dangerous malaria species, the host-derived immunity is often insufficient to completely inhibit the infection cycles of the parasite in red blood cells for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.

引用

页码：169 / 186

页数：18

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