Role of Heat Shock Proteins in Immune Modulation in Malaria

被引：1
作者：
Zininga, Tawanda [1 ]
Boettger, Evelyn [2 ]
Multhoff, Gabriele [3 ,4 ]
机构：
[1] Stellenbosch Univ, Dept Biochem, Stellenbosch, South Africa
[2] Univ Tubingen, Inst Trop Med, Tubingen, Germany
[3] Tech Univ Munich, TranslaTUM, Klinikum Rechts Isar, Klin & Poliklin Strahlentherapie & Radiol Onkol, Munich, Germany
[4] Tech Univ Munich, TranslaTUM, Cent Inst Translat Canc Res, Munich, Germany
来源：
HEAT SHOCK PROTEINS OF MALARIA, 2ND EDITION | 2021年 / 1340卷
关键词：
Parasite heat shock protein; Granzyme B; Natural killer cell; Immunotherapy; Eryptosis; Infected erythrocyte; NATURAL-KILLER-CELLS; PLASMODIUM-FALCIPARUM; SQUIRREL-MONKEY; GRANZYME-B; T-CELLS; HSP70; CHAPERONE; MEMBRANE; STRESS; HEAT-SHOCK-PROTEIN-70;
D O I：
10.1007/978-3-030-78397-6_7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Malaria is one of the major parasitic killer diseases worldwide. Severe cases of malaria are mostly in children under the age of 5 years due to their naive immune system and in pregnant women with weakened immune responses. Inflammatory immune responses against the parasite involve complement activation as well as the antibody and effector cell-mediated immune system. However, after an infection with Plasmodium falciparum (P. falciparum), the most dangerous malaria species, the host-derived immunity is often insufficient to completely inhibit the infection cycles of the parasite in red blood cells for yet unknown reasons. In the present chapter we aim to elucidate the role of the host's and the parasite's heat shock proteins (HSPs) in the development of a novel anti-malaria therapeutic approach.
引用
收藏
页码：169 / 186
页数：18
相关论文
共 131 条
  • [1] Differential expression pattern of co-inhibitory molecules on CD4+ T cells in uncomplicated versus complicated malaria
    Abel, Annemieke
    Steeg, Christiane
    Aminkiah, Francis
    Addai-Mensah, Otchere
    Addo, Marylyn
    Gagliani, Nicola
    Casar, Christian
    Yar, Denis Dekugmen
    Owusu-Dabo, Ellis
    Jacobs, Thomas
    Mackroth, Maria Sophia
    [J]. SCIENTIFIC REPORTS, 2018, 8
  • [2] Chaperoning a cellular upheaval in malaria:: Heat shock proteins in Plasmodium falciparum
    Acharya, Pragyan
    Kumar, Ranjit
    Tatu, Utpal
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2007, 153 (02) : 85 - 94
  • [3] An Exported Heat Shock Protein 40 Associates with Pathogenesis-Related Knobs in Plasmodium falciparum Infected Erythrocytes
    Acharya, Pragyan
    Chaubey, Shweta
    Grover, Manish
    Tatu, Utpal
    [J]. PLOS ONE, 2012, 7 (09):
  • [4] Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
    Aprile, Francesco A.
    Dhulesia, Anne
    Stengel, Florian
    Roodveldt, Cintia
    Benesch, Justin L. P.
    Tortora, Paolo
    Robinson, Carol V.
    Salvatella, Xavier
    Dobson, Christopher M.
    Cremades, Nunilo
    [J]. PLOS ONE, 2013, 8 (06):
  • [5] Arispe N, 2002, CELL STRESS CHAPERON, V7, P330, DOI 10.1379/1466-1268(2002)007<0330:LIDTCA>2.0.CO
  • [6] 2
  • [7] Interaction of heat shock protein 70 with membranes depends on the lipid environment
    Armijo, Gabrielle
    Okerblom, Jonathan
    Cauvi, David M.
    Lopez, Victor
    Schlamadinger, Diana E.
    Kim, Judy
    Arispe, Nelson
    De Maio, Antonio
    [J]. CELL STRESS & CHAPERONES, 2014, 19 (06) : 877 - 886
  • [8] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    Asea, A
    Kraeft, SK
    Kurt-Jones, EA
    Stevenson, MA
    Chen, LB
    Finberg, RW
    Koo, GC
    Calderwood, SK
    [J]. NATURE MEDICINE, 2000, 6 (04) : 435 - 442
  • [9] LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction
    Atochina, O
    Harn, D
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (09) : 1041 - 1049
  • [10] BALEUX F, 1992, INT J PEPT PROT RES, V40, P7
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