Nanotherapeutics for anti-inflammatory delivery

被引：26
作者：
Di Marzio, Luisa [1 ]
Ventura, Cinzia Anna [2 ]
Cosco, Donato [3 ]
Paolino, Donatella [3 ]
Di Stefano, Antonio [1 ]
Stancanelli, Rosanna [2 ]
Tommasini, Silvana [2 ]
Cannava, Carmela [4 ]
Celia, Christian [1 ]
Fresta, Massimo [3 ]
机构：
[1] Univ Chieti Pescara G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy
[2] Univ Messina, Dept Drug Sci & Hlth Prod, Polo Univ Viale SS Annunziata SNC, I-98168 Messina, Italy
[3] Univ Catanzaro Magna Graecia, Dept Hlth Sci, Bldg Biosci,Viale S Venuta,Univ Campus S Venuta, I-88100 Catanzaro, Italy
[4] Univ Messina, Dept Human Pathol, Policlin Univ, Via Consolare Valeria 1, I-98125 Messina, Italy
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2016年 / 32卷
关键词：
Nonotherapeutics; Anti-inflammatory drug; Colloidal nanoparticles; Natural products; NF-KAPPA-B; CYCLODEXTRIN INCLUSION COMPLEX; IN-VIVO EVALUATION; DRUG-DELIVERY; ANTICANCER ACTIVITY; ESSENTIAL OIL; AMMONIUM GLYCYRRHIZINATE; TRANSDERMAL DELIVERY; LIPID NANOPARTICLES; COLLOIDAL CARRIERS;
D O I：
10.1016/j.jddst.2015.10.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The science innovations improved the patient quality of life and perspectives. In particular, the revolutionary turmoil of the second half of twentieth century in the Science Academia poses the milestone to develop innovative supramolecular nanotherapeutics and enforce nanotechnology and drug delivery. The driving force of this revolution was the synthesis of novel, safe and biocompatible nanomaterials, which can be easily combined to design new supramolecular nanotherapeutics. Additionally, these innovative nanomaterials can, per se or as supramolecular nanocarriers, deliver bioactive compounds, which show different physical-chemical features, and treat different diseases. Recently, pharmaceutical industry and academia show a specific interest for natural products, which emerge as potential new drug candidates for the therapeutic treatment of inflammatory pathologies. In fact, the delivery of natural products by using supramolecular nanotherapeutics can represent a great opportunity in nanomedicine and an alternative therapeutic option to conventional medicine for treating inflammatory diseases. In this review, we will discuss the recent innovation of supramolecular nanotherapeutics delivering natural anti-inflammatory compounds and provide an overview of their application in nanomedicine. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：174 / 191
页数：18
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