The Expression and Clinical Significance of TGF-β1 and MMP2 in Human Renal Clear Cell Carcinoma

被引：15
作者：
Yang, Shu-dong [1 ]
Sun, Rong-chao [1 ]
Mu, Hui-jun [2 ]
Xu, Zhuo-qun [3 ]
Zhou, Zhi-yi [1 ]
机构：
[1] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Pathol, Wuxi 214023, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Wuxi Peoples Hosp, Cent Lab, Wuxi 214023, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Urol, Wuxi 214023, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2010年 / 18卷 / 02期
关键词：
renal clear cell carcinoma; TGF-beta; 1; MMP2; immunohistochemistry; reverse transcription-polymerase chain reaction; MATRIX-METALLOPROTEINASE EXPRESSION; TUMOR PROGRESSION; TGF-BETA; CANCER; GELATINASES; METASTASIS; ACTIVATION; PHENOTYPE; ANTIGENS; INVASION;
D O I：
10.1177/1066896909331993
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The expression and clinical significance of transforming growth factor beta 1 (TGF-beta 1) and matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. The intensity of TGF-beta 1 and MMP2 expression in RCCC kidneys was significantly higher than that in normal kidneys. Expression of TGF-beta 1 and MMP2 in RCCC tissues was positively correlated with pathological grade and clinical stage. There was also a significant correlation between TGF-beta 1 and Msshese analyses indicate that upregulation of TGF-beta 1 and MMP2 expression may occur during the progression of RCCC. Thus, TGF-beta 1 and MMP2 may be useful molecular markers for evaluating prognosis in RCCC patients.
引用
收藏
页码：85 / 93
页数：9
相关论文
共 24 条
[1]  
Deryugina EI, 2000, INT J CANCER, V86, P15, DOI 10.1002/(SICI)1097-0215(20000401)86:1<15::AID-IJC3>3.0.CO
[2]  
2-B
[3]   Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion [J].
Di Nezza, LA ;
Misajon, A ;
Zhang, J ;
Jobling, T ;
Quinn, MA ;
Östör, AG ;
Nie, GY ;
Lopata, A ;
Salamonsen, LA .
CANCER, 2002, 94 (05) :1466-1475
[4]   Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura [J].
Edwards, JG ;
McLaren, J ;
Jones, JL ;
Waller, DA ;
O'Byrne, KJ .
BRITISH JOURNAL OF CANCER, 2003, 88 (10) :1553-1559
[5]   Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model [J].
Fang, JM ;
Shing, Y ;
Wiederschain, D ;
Yan, L ;
Butterfield, C ;
Jackson, G ;
Harper, J ;
Tamvakopoulos, G ;
Moses, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :3884-3889
[6]   Levels of angiogenesis and expression of angiogenesis-related genes are prognostic for organ-specific metastasis of renal cell carcinoma [J].
Fukata, S ;
Inoue, K ;
Kamada, M ;
Kawada, C ;
Furihata, M ;
Ohtsuki, Y ;
Shuin, T .
CANCER, 2005, 103 (05) :931-942
[7]   From TGF-β to cancer therapy [J].
Huang, XM ;
Lee, C .
CURRENT DRUG TARGETS, 2003, 4 (03) :243-250
[8]   Attenuated type II TGF-B receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination [J].
Huntley, SP ;
Davies, M ;
Matthews, JB ;
Thomas, G ;
Marshall, J ;
Robinson, CM ;
Eveson, JW ;
Paterson, IC ;
Prime, SS .
INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (02) :170-176
[9]   Altered pattern of major histocompatibility complex expression in renal carcinoma - Tumor-specific expression of the nonclassical human leukocyte antigen-G molecule is restricted to clear cell carcinoma while up-regulation of other major histocompatibility complex antigens is primarily distributed in all subtypes of renal carcinoma [J].
Ibrahim, EC ;
Allory, Y ;
Commo, F ;
Gattegno, B ;
Callard, P ;
Paul, P .
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) :501-508
[10]   Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix [J].
Ivaska, J ;
Heino, J .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (01) :16-24
123