APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

被引：29

作者：

Beckerman, Pazit ^{[1
,2
,3
]}

Susztak, Katalin ^{[1
,2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[3] Sheba Med Ctr, Inst Nephrol & Hypertens, Tel Hashomer, Israel

来源：

TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 08期

关键词：

TRYPANOSOME LYTIC FACTOR; STAGE RENAL-DISEASE; RESISTANCE-ASSOCIATED PROTEIN; LIPID-BINDING PROTEIN; RISK VARIANTS; APOLIPOPROTEIN L1; AFRICAN TRYPANOSOMES; FUNCTION DECLINE; INNATE IMMUNITY; GENE VARIANTS;

D O I：

10.1016/j.molmed.2018.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic kidney disease (CKD) affects millions of people and constitutes a major health and financial burden worldwide. People of African descent are at an increased risk of developing kidney disease, which is mostly explained by two variants in the Apolipoprotein L1 (APOL1) gene that are found only in people of west African origin. It is hypothesized that these variants were genetically selected due to the protection they afford against African sleeping sickness, caused by the parasite Trypanosoma brucei. Targeting mutant APOL1 could have substantial therapeutic potential for treating kidney disease. In this review, we will describe the intriguing interplay between microbiology, genetics, and kidney disease as revealed in APOL1-associated kidney disease, discuss APOL1-induced cytotoxicity and its therapeutic implications.

引用

页码：682 / 695

页数：14

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