Antibody responses to α-Gal in African children vary with age and site and are associated with malaria protection

被引：27

作者：

Aguilar, Ruth ^{[1
]}

Ubillos, Itziar ^{[1
]}

Vidal, Marta ^{[1
]}

Balanza, Nuria ^{[1
]}

Crespo, Nuria ^{[1
]}

Jimenez, Alfons ^{[1
,2
]}

Nhabomba, Augusto ^{[3
]}

Jairoce, Chenjerai ^{[3
]}

Dosoo, David ^{[4
]}

Gyan, Ben ^{[4
]}

Ayestaran, Aintzane ^{[1
]}

Sanz, Hector ^{[1
]}

Campo, Joseph J. ^{[1
]}

Gomez-Perez, Gloria P. ^{[1
]}

Izquierdo, Luis ^{[1
]}

Dobano, Carlota ^{[1
]}

机构：

[1] Hosp Clin Univ Barcelona, ISGlobal, Barcelona, Spain

[2] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[3] CISM, Maputo, Mozambique

[4] Kintampo Hlth Res Ctr, Kintampo, Ghana

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

BLOOD-STAGE ANTIGENS; PLASMODIUM-FALCIPARUM; IMMUNOGLOBULIN-G; GALACTOSYL ANTIBODIES; CLINICAL MALARIA; IMMUNE-RESPONSE; MARGINAL ZONE; GDP-FUCOSE; CARBOHYDRATE; VACCINE;

D O I：

10.1038/s41598-018-28325-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Naturally-acquired antibody responses to malaria parasites are not only directed to protein antigens but also to carbohydrates on the surface of Plasmodium protozoa. Immunoglobulin M responses to alpha-galactose (alpha-Gal) (Gal alpha 1-3Gal beta 1-4GlcNAc-R)-containing glycoconjugates have been associated with protection from P. falciparum infection and, as a result, these molecules are under consideration as vaccine targets; however there are limited field studies in endemic populations. We assessed a wide breadth of isotype and subclass antibody response to alpha-Gal in children from Mozambique (South East Africa) and Ghana (West Africa) by quantitative suspension array technology. We showed that anti-alpha-Gal IgM, IgG and IgG(1-4) levels vary mainly depending on the age of the child, and also differ in magnitude in the two sites. At an individual level, the intensity of malaria exposure to P. falciparum and maternally-transferred antibodies affected the magnitude of alpha-Gal responses. There was evidence for a possible protective role of anti-alpha-Gal IgG3 and IgG4 antibodies. However, the most consistent findings were that the magnitude of IgM responses to alpha-Gal was associated with protection against clinical malaria over a one-year follow up period, especially in the first months of life, while IgG levels correlated with malaria risk.

引用

页数：15

共 63 条

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