Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy

被引：24

作者：

Notturno, Francesca ^{[1
]}

Di Febo, Tiziana ^{[2
]}

Yuki, Nobuhiro ^{[3
,8
]}

Rodriguez, Blanca M. Fernandez ^{[4
]}

Corti, Davide ^{[4
]}

Nobile-Orazio, Eduardo ^{[5
]}

Carpo, Marinella ^{[6
]}

De Lauretis, Angelo ^{[7
]}

Uncini, Antonino ^{[1
]}

机构：

[1] Univ G DAnnunzio, Dept Neurosci & Imaging, I-66100 Chieti, Italy

[2] Expt Zooprophylact Inst Abruzzo & Molise G Capora, Teramo, Italy

[3] Natl Univ Singapore, Dept Med, Singapore 117548, Singapore

[4] Inst Biomed Res, Bellinzona, Switzerland

[5] Univ Milan, IRCCS Humanitas Clin Inst, Dept Med Biotechnol & Translat Med, Milan, Italy

[6] Osped Treviglio, Neurol Unit, Bergamo, Italy

[7] Univ Cattolica Sacro Cuore, Dept Resp Med, I-00168 Rome, Italy

[8] Natl Univ Singapore, Dept Physiol, Singapore 117548, Singapore

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 276卷 / 1-2期

关键词：

Chronic inflammatory demyelinating neuropathy; Gliomedin; Neurofascin; Multifocal motor neuropathy; GUILLAIN-BARRE-SYNDROME; MYELINATED NERVE-FIBERS; ANTI-GM1; ANTIBODIES; SALTATORY CONDUCTION; TARGET; DISRUPTION; DIAGNOSIS; CURRENTS; RANVIER; DOMAIN;

D O I：

10.1016/j.jneuroim.2014.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n = 53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n = 95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：207 / 212

页数：6

共 21 条

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